摘要
目的观察黄连解毒汤加味合并氯氮平治疗精神分裂症患者伴有兴奋激越症状的疗效与不良反应。方法160例患者随机分为黄连解毒汤合并氯氮平组(研究组)80例,单用氯氮平组(对照组)80例。治疗前后以简明精神病量表(BPRS)激越分减分率评定疗效,以副反应量表(TESS)评估不良反应。结果治疗后2周研究组有效率为82.5%,对照组为72.5%,研究组优于对照组(P<0.05);两组在治疗后72h、1周和2周时BPRS各激越因子分均较治疗前显著下降,并且研究组优于对照组(P<0.05或P<0.01);研究组较对照组副反应较少。结论黄连解毒汤加味对精神分裂症有一定的治疗作用,中西医结合治疗精神分裂症优于单纯西药,并且毒副作用较小。
Objective To study the effect and safety of Modified Huanglian Jiedu Decoction （Detoxicant Coptis Decoction） combined with elozapine in the treatment of schizophrenia with exeitationt and agitation. Methods Totally 160 inpatients were divided into two groups. The study group, 80 cases, was treated with Modified Huanglian Jiedu Decoction combined with clozapine, and the control group, 80 cases, treated with clozapine only. The Brief Psychiatric Rating Scale （BPRS） and Treatment Emergent Symptom Scale （TESS） were used to evaluate the effect and safety. Results The effective rate of study group and control group was 82.5% and 72.5% respectively at the end of the second week of treatment, the study group being better than the control group （P〈0.05）. The agitation factors in BPRS of both groups at 72h, one week and two weeks after treatment were significantly decreased compared with those before treatment, and the study group was supperior to the control group （P〈0. 05 or P〈0. 01）. The side effect in the study group was less than that in the control group. Conclusion Modified Huanglian Jiedu Decoction is effective for schizophrenia. The effect of Chinese medicine combined with clozapine is better than western medicine only with less side effect.
出处
《中医杂志》
CSCD
北大核心
2009年第6期510-512,共3页
Journal of Traditional Chinese Medicine
基金
山东省聊城市科学技术局资助项目(2008-062)
关键词
精神分裂症
兴奋激越
黄连解毒汤加味
氯氮平
临床研究
Schizophredia
Excitation and agitation
Modified Huanglian Jiedu Decoction （Detoxicant Coptis Decoction）
Clozapine
Clinical study
