期刊文献+

GP和FP治疗转移性鼻咽癌的疗效观察 被引量:1

Clinical observation on the efficacy of combination gencitabine plus cisplatin and combination 5-FU plus cisplatin chemotherapy for metastatic nasopharyngeal carcinoma
下载PDF
导出
摘要 目的:观察吉西他滨+顺铂(GP)方案和氟尿嘧啶+顺铂(FP)方案治疗晚期复发转移性鼻咽癌的疗效及不良反应。方法:选择放疗后复发转移性鼻咽癌60例,分别采用GP方案或FP方案静脉化疗,21天为1周期。结果:GP组:CR5例、PR19例,有效率(CR+PR)80%;FP组:CR2例、PR14例,有效率(CR+PR)53.3%两组有效率有显著差异(P=0.0283)。中位PFS(无进展生存期)GP组8个月,FP组3个月(P=0.0001)。中位OS期(总生存期)GP组11个月,FP组7个月(P=0.0002)。两组毒性均能耐受。结论:GP方案较FP可以更好改善复发转移性鼻咽癌的RR、PFS和OS。 Objective:To observe the efficacy and toxicity of combination gencitabine plus cisplatin (GP) and combination 5 -FU plus cisplatin (FP) chemotherapy for metastatic nasopharyngeal carcinoma. Methods: Sixty pa tients (all cases had been treated with radiotherapy) with metastatic nasopharyngeal carcinoma received GP or FP chemotherapy every 21 days. Results:In group GP:5 patients CR, 19 patients PR,4 patients SD,2 patients PD, RR (CR + PR) 80 % ;group FP:2 patients CR,14 patients PR,8 patients SD,6 patients PD,RR(CR + PR) 53.3%. The median progression -free survival (PFS) was 8 months and 3 months, respectively. The median overall survival (OS) was 11 months and 7 months. Toxicity was mild in both groups. Conclusion:GP regimen for metastatic nasopharyngeal carcinoma is more effective.
出处 《现代肿瘤医学》 CAS 2009年第7期1238-1240,共3页 Journal of Modern Oncology
关键词 吉西他滨 氟尿嘧啶 顺铂 鼻咽癌 化学治疗 gencitabine 5 - FU cisplatin nasopharyngeal chemotherapy
  • 相关文献

参考文献11

  • 1Chan AT, Teo PM, Leung TW, et al. The role of chemotherapy in the management of nasopharyngeal carcinoma [ J ]. Cancer, 1998,82 (6) :1003 - 1012.
  • 2王树森,管忠震.鼻咽癌化学治疗研究现状与展望[J].肿瘤防治杂志,2004,11(4):422-424. 被引量:13
  • 3陈森.局部复发鼻咽癌的治疗现状[J].现代肿瘤医学,2007,15(8):1201-1203. 被引量:3
  • 4Ma BB, Chan AT. Recent perspectives in the role of chemotherapy in the management of advanced nasopharyngeal carcinoma [ J ]. Cancer,2005,103 ( 1 ) :22 -31.
  • 5Foo KF, Tan EH, Leong SS, et al. Gemcitabine in metastatic nasopharyngeal carcinoma of the undifferentiated type [ J ]. Ann Oncol, 2002,13 ( 1 ) : 150 - 156.
  • 6Ma BB, Tannock IF, Pond GR, et al. Chemotherapy with gemcitabine containing regimens for locally recurrent or metastatic nasopharyngeal carcinoma[ J]. Cancer,2002,95 (12) :2516 - 2523.
  • 7Ngan RK, Yiu HH, Lau WH, et al. Combination gemcitabine and cisplatin chemotherapy for metastatic or recurrent nasopharyngeal carcinoma:report of a phase Ⅱ study[Jl. Ann Oncol,2002,13 (8) :1252 - 1258.
  • 8洪茜,周桑玉,陈志坚,彭培建.吉西他滨联合顺铂治疗复发或转移性鼻咽癌的临床研究[J].实用癌症杂志,2005,20(6):619-621. 被引量:6
  • 9任剑,王迪进,李林.吉西他宾联合顺铂治疗晚期鼻咽癌30例[J].实用中西医结合临床,2007,7(6):61-61. 被引量:1
  • 10Leong SS, Wee J,Tay MH, et al. Paclitaxel, corboplatin, and gemcitabine in metastatic nasopharyngeal carcinoma, a phase Ⅱ trial using a triplet combination[ J]. Cancer 2005,103 ( 3 ) :569 - 575.

二级参考文献34

共引文献18

同被引文献12

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部