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P14ARF、E2F1对结直肠癌发生发展的影响 被引量：2

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摘要 肿瘤抑制因子P14ARF通过p53-MDM2-P14ARF细胞周期调节系统使细胞老化或凋亡,对肿瘤的发生发展起重要的抑制作用;E2F1可以作为转录因子参与调节细胞周期,然而高表达的E2F1也能诱导许多类型的细胞凋亡,因此E2F1具有促使癌变和诱导凋亡双向性质;P14ARF和E2F1直接影响肿瘤的发生、发展和预后,这关系着患者治疗方案的选择,因而日益受到重视。本文章旨在探讨P14ARF、E2F1与人结直肠癌发生发展的关系,就其机制和影响综述如下。
作者 沈勤 王芳
机构地区 湖北十堰郧阳医学院附属医院东风总医院病理科 昆明医学院病理研究室
出处 《现代肿瘤医学》 CAS 2009年第7期1391-1393,共3页 Journal of Modern Oncology
关键词 P14ARF E2F1 结直肠癌
分类号 R735.34 [医药卫生—肿瘤]
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现代肿瘤医学
2009年 第7期

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