摘要
Objective and Methods The key cause of failure to cure and high mortality in lung cancer. At present, it has been known
Objective and Methods The key cause of failure to cure and high mortality in lung cancer. At present, it has been known that lung cancer metastasis was controlled by many genes, especially the tumor metastatic suppressive gene. nm23 gene was discovered in 1988 as a first and the most important tumor metastatic suppressive gene. It has been proved that a close correlation existed between the high metastatic rate and the low expression or alleic deletion ofnm23-H1 gene by DNA, mRNA and protein levels in lung cancer, The lung cancer with nm23-H1 gene deletion is always combined with abnormal expression of some other metastastic-related genes. Dr. Zhou Qinghua has hypothesized that nm23-H1 gene may be an upstpeam regulatory gene of metastatic-related genes and it can regulate the downstream genes to inhibit metastasis. In order to explore the effect of nrn23-H1 gene on cytoskeleton and biological behavior of human lung cancer and the molecular mechanisms regulating the cytoskeleton of lung cancer cell,
出处
《中国肺癌杂志》
CAS
2009年第6期475-476,共2页
Chinese Journal of Lung Cancer
基金
supported by the grants from the Key Project of National Natural Science Foundation of China (No .30430300 , to Qinghua ZHOU)
Key Projects of Tian-jin Sci-Tech Support Program (No . 07SY SY SF05000 and No 06YFSZSF05300, to Qinghua ZHOU)
关键词
肺癌
治疗
诊断
疗效
Lung cancer cell line L9981
Nm23-H1 gene
Cytoskeleton
Invasion and metastasis
