摘要
Background and objective Invasion and metastasis is not only the malignant phenotypes of lung cancer but also the main cause of death. Elucidating the molecular mechanism of
Background and objective Invasion and metastasis is not only the malignant phenotypes of lung cancer but also the main cause of death. Elucidating the molecular mechanism of tumor invasion and metastasis will provide new molecular targets for targeting terapy of lung cancer. Invasion and metastasis is complex multi-step process involving activation of tumor metastasis genes as well as inactivation of tumor metastasis suppressor genes. Nm23-HI gene is originally identified as a tumor metastasis suppressor gene whose alteration is demonstrated to be closely related to many malignant tumor metastases. The reduced expression and hetero-deletion ofnm23-H1 gene have been proved to be closely correlated with the high metastasis potential and poor prognosis of lung cancer. In addition, the abnormality of nm23-H1 gene is often companied with the changes of tumor metastasis-related genes. As a result, Dr. Odnghua Zhou from China hypothesized that there was a ＂Lung Cancer Metastatic Suppressive Cascade＂ in lung cancer and nm23-H1 might serve as an upstream regulatory gene to inhibit lung cancer metastasis by regulating downstream genes of this cascade.
出处
《中国肺癌杂志》
CAS
2009年第6期490-492,共3页
Chinese Journal of Lung Cancer
基金
supported by grants from the Key Project of National Natural Science Foundation of China (to Qinghua ZHOU) (No.30430300)
National Natural Science Foundation of China (to Qinghua ZHOU) (No.30070333)
关键词
NM23-H1
肺癌
临床
治疗
Nm23-HI gene
＂Lung Cancer Metastatic Suppres-sion Cascade＂
Gene transfection
L9981 lung cancer cell line
Tumor metastasis
