摘要
Background and objective Lung cancer has not only become the most frequent malignant cancer which is increasing fastest among all the tumors, but also become the rst killer
Background and objective Lung cancer has not only become the most frequent malignant cancer which is increasing fastest among all the tumors, but also become the first killer which threatens human health and life in the world. Tumor invasion and metastasis are the key causes that result in failure to cure and patient＇s death, it has been proved that the invasion and metastasis of lung cancer is regulated by multiple genes, which is extremely complicated. In this process, some genes act as positive regulator, and the others act as negative regulator. Many studies have proved that there is a significant relationship between decreased expression of nm23-H1 and an aspect of aggressive clinical course （patient survival, lymph node metastasis） in lung cancer, while MAPK pathway may be the downsteam signaling cascade that involved in the process of nm23-H1 on suppressing lung cancer＇s metastasis. Kinase sppressor of Ras （KSR） is a novel gene which was discovered in 1995. Its function is mainly as a scaffold protein that coordinates the assembly of a multipro- rein complex containing MAPK and its upstream regulators and thus accelerates the signal transduction of MAPK pathway.
出处
《中国肺癌杂志》
CAS
2009年第6期494-496,共3页
Chinese Journal of Lung Cancer
基金
supported by a grant from the key project of the National Natural Science Foundation of China (to Qinghua ZHOU) (No. 30430300)
National Natural Science Foundation of China (to Qinghua ZHOU) (No. 30670922)
INTERNATION Scienc and Techniquie COOPRATION PROGRAM OF CHINA (ISCP) (to Qinghua ZHOU)(No.2006DFB32330)
关键词
NDPK
肺癌
临床
治疗
Nm23-HI gene
KSR
MAPK pathway
Lung cancer
