摘要
评价大剂量醛氢叶酸（HDCF）、氟脲嘧啶（5－Fu）、长春新碱（VCR）、甲环亚硝脲（Me－CCNU）联合治疗晚期大肠癌疗效。方法：经病理证实的晚期大肠癌38例，其中术后复发的25例，不能手术的13例（均为DukesD）。CF200mg／m2静滴2小时第1～4天，5－Fu500mg／m2静推（在CF静滴一半时）第1～4天，VCR1．4mg／m2静推第1、8天。上述药物每3周重复；Me－CCNU175mg／m2第1天口服，每6周重复。结果：全组CRO例，PR17例，总有效率（CR＋PR）44．7％（17／38），其中术后复发的有效率44％（11／25）。不能手术的有效率46．2％（6／13）。毒副反应主要为口腔炎、腹泻、白细胞及血小板下降、色素沉着，但多为Ｉ－Ⅱ级毒性反应。结论：本方案疗效较高，毒性反应可以耐受，因此值得在临床治疗晚期大肠癌中作进一步的探讨。
To evaluate the efficacy of the combination of high dose leucovorin(HDCF), Fluorouracil (5-- Fu), Vincristine (VCR) and Semustine (Me -- CCNU) in patients with advanced coloretai cancer.Method: 38 cases of histologically confirmed advanced colometal cancer had been studied in thes clinical trial. 25 of them were patients with postoperative relapse and 13 of them were inoperable advanced patients (Dukes D). CF 200 mg/m2 infusion was given in 2hrs for day 1 ~ 4;5 -- Fu 500 mg/mZ2 i. v was started while HDCF was given half way for day 1 ~ 4;VCR 1 .4 nmg/m2,i. v was given for day 1 to day 8;the above medicines were recycled every 3 weeks. Me -- CCNU was given orally on day 1 and recycled every 6 weeks. Results:This tall showed that 0 case achieved CR, 17 cases PR and the overall asponse rate (CR + PR) was 44. 7%. The response rate of inopevable advanced patients was 46. 2% (6/13) and that of the patients with pstoperative relapse was 44% (11/25). The main toxic side effects included stomatitis,diarrhea , leucopenia and thrombocytopenia , which were mostly of Ⅰ ~ Ⅱ Grade (WHO Classification). Conclusions: This pilot study showed that the regimen is an effective treatment for advanced colorectal cancer because the overall toxicity is reversible and tolerable it is worthy of further study.
出处
《河南肿瘤学杂志》
1998年第3期187-189,共3页
Henan Journal of Oncology
