摘要
视神经脊髓炎(NMO)是主要累及视神经和脊髓的特发性炎性脱髓鞘和致坏死性疾病。在NMO患者血清中发现一种与水通道蛋白4(AQP4)结合的自身IgG抗体(NMO-IgG)。NMO-IgG并非在NMO患者血清中发现的唯一自身抗体,但与正常高表达AQP4的中枢神经系统的组织病理关系说明NMO-IgG可能具有致病性。就AQP4在NMO发病中的作用,AQP4的B细胞表位和发病的关系以及AQP4特异性B细胞和T细胞的启动进行综述。
Neuromyelitis optica（NMO） is a severe idiopathic immuno-mediated inflammatory demyelinating and necrotizing disease that predominantly involves the optic nerve and spinal cord. An IgG autoantibody（NMO-IgG） ,which can binds aquaporin 4（AQP4） ,has been identified in the sera of NMO patients. NMO-IgG is not the only autoantibody found in sera of NMO patient, but the correlation of pathology of central nervous system （CNS） with some tissues that normally express high level of AQP4 suggests that NMO-IgG might be pathogene. It is important to identify and understand the mechanism of an immune responseinduced against AQP4. This review focuses on the AQP4 associated with pathogenesis of NMO and AQP4 B cell epitopes and explores its relationship to pathogenesis,priming of AQP4-specific B and T cells.
出处
《眼科研究》
CSCD
北大核心
2009年第7期637-640,共4页
Chinese Ophthalmic Research
