摘要
目的:优选扶正解毒颗粒的制备工艺。方法:以人参皂苷Re收率为指标,应用正交设计试验优选扶正解毒颗粒的提取工艺。结果:影响人参皂苷Re水提的主次因素由大到小排列依次是A>D>B>C(A为加水量、B为浸泡时间、C为煎煮时间、D为煎煮次数),优选的提取工艺为加水量为药材量的15倍,浸泡3h,每次煎煮4h,煎煮2次;优选的流化喷雾制粒工艺条件为流化喷雾制粒膏粉比为2∶1,稠浸膏相对密度为1.30(25℃测定),喷液电压为120V,每批料抖袋65个周期(每个抖袋周期来回抖袋2次)。结论:优选的制备工艺稳定、可行。
Objective： To optimize the preparation process of Fuzheng Jiedu Granules. Methods： The gain rate of ginsenoside Re was taken as the index, the preparation process condition of Fuzheng Jiedu Granules was optimized by the orthogonal design. Results： The factors influencing the extraction amount of ginsenoside Re was as follows, A〉D〉B〉C（A： the amount of water added, B： the soak time, C： the extraction time, D： times of extraction）. The optimum percolation condition obtained was to add 15 times of water and soak for 3 hours, decoct twice, 4 hours each time. The optimum conditions of granulation by sprayer were that the fluid extract was 2 times of powder in weight; the relative density of the fluid extract was 1.30 （measured at 25℃）, the voltage of sprayer was 120 V, the period of bag shaking was 65 times （shaking bag back and forth twice in each period）. Conclusion： The results of the experiment shows that the preparation process of Fuzheng Jiedu Granules is stable and applicable.
出处
《中国医药导报》
CAS
2009年第20期48-50,共3页
China Medical Herald
基金
宜宾市科技局科研项目(200703014)
关键词
扶正解毒颗粒
正交设计试验
工艺研究
Fuzheng Jiedu Granules
Orthogonal design
Study on preparation process
