摘要
目的探讨丹参酮ⅡA对2型糖尿病患者氧化应激的影响作用。方法选取2型糖尿病患者53例(其中51例完成研究)为DM组,选取糖耐量正常的健康体检者(OGTT正常)50例作为正常对照组(NC组)。DM组在原降糖的基础上,每日加用丹参酮ⅡA磺酸钠注射液60mg,共2周。于治疗开始时和治疗后2周,抽取早晨空腹外周静脉血检测血清超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH)、活性氧(ROS)活性和丙二醛(MDA)水平以及空腹血糖和胰岛素水平等。观察DM组患者治疗前后氧化应激指标变化、相关临床指标并与NC组作比较。结果DM组的ROS和MDA显著高于NC组(P<0.05或P<0.01),而GSH和SOD显著低于NC组(P<0.05)。与治疗前相比,治疗后DM组患者的ROS和MDA明显下降(P<0.05)、GSH和SOD明显升高(P<0.05),经校正血糖变化值后,差异仍具有统计学意义(P<0.05)。结论丹参酮ⅡA对2型糖尿病患者具有抗氧化应激作用,可用于糖尿病及其并发症的防治。
Objective To investigate the effect of tanshinone ⅡA on oxidative stress in patients with type 2 diabetes. Methods The fasting serum levels of reduced glutathione hormone （GSH）, superoxide dismutase （SOD）, reactive oxygen species （ROS）, malonaldehyde （MDA） ,were tested in 50 subjects with normal glucose tolerant（NGT） and 51 subjects with type 2 diabetes（DM） before and after treatment of tanshinone ⅡA. Results The fasting serum levels of GSH and SOD were significantly lower in subjects with DM than those in subjects with NGT （P〈0.05）,the fasting serum levels of ROS and MDA were significantly higher in subjects with DM than those in subjects with NGT （P〈0.05 or P〈0.01）. After treatment of tanshinone ⅡA,The fasting serum levels of GSH and SOD were significantly reduced, and the fasting serum levels of ROS and MDA were significantly increased, there were still stastically significant difference（P〈0. 05） after adjusting for reduction of fasting blood glucose（FBG）. Conclusion Tanshinone ⅡA could reduce oxidative stress in patients with type 2 diabetes.
出处
《江西医学院学报》
CAS
2009年第4期90-92,95,共4页
Acta Academiae Medicinae Jiangxi
