摘要
目的:观察急性冠状动脉综合征(ACS)患者介入治疗前后血小板活化指标P选择素(CD62p)、糖蛋白(GP)Ⅱb/Ⅲa受体复合物、纤维蛋白原(FIB-C)和血管内炎症指标高敏C反应蛋白(hs-CRP)的变化及其临床意义。方法:100例ACS患者冠状动脉介入治疗(PCI)术前和术后次日凌晨分别空腹采肘静脉血用流式细胞仪检测定血清CD62p和GPⅡb/Ⅲa受体复合物的表达水平;用散射比浊法测定血浆FIB-C的水平;用乳胶免疫增强比浊法测定血清hs-CRP的水平。选择健康体检者40例和稳定型心绞痛患者50例作对照,观察ACS患者PCI前后指标的变化并与对照组比较。结果:ACS患者中,不稳定型心绞痛(UAP)组血清CD62p、GPⅡb/Ⅲa、FIB-C和hs-CRP的表达水平均明显高于健康对照组(均P<0.01)和稳定型心绞痛(SAP)组(分别P<0.05,P<0.01,P<0.05,P<0.01);急性心肌梗死(AMI)组明显高于UAP组(分别P<0.05,P<0.01,P<0.05,P<0.01)。冠状动脉病变程度不同上述指标也有所不同,急性闭塞组高于3支病变组(P<0.05),3支病变组高于双支病变组(均P<0.05),双支病变组较单支病变组也明显增高(分别P<0.05,P<0.05,P<0.05,P<0.01)。UAP和AMI组PCI术后CD62p、GPⅡb/Ⅲa、FIB-C和hs-CRP的水平较术前均有显著性增高(均P<0.01)。结论:血小板活化和炎症反应在ACS发生和发展过程中起了重要的作用,PCI术后血小板和炎症反应物质有一定程度的激活。
Objective：To observe the changes of serum level of the CD62p,glucose protein （GP） Ⅱb/Ⅲa, Fibrinogen C（FIE C）and high sensitivity C-reaction protein（hs-CRP） which indicate the platelet activity and vascular inflammation after percutaneous coronary intervention（PCI） in patients with acute coronary syndrome（ACS） and explore their clinical significances. Methods： We examined the blood express levels of CD62p, GP Ⅱb/Ⅲa, FIB-C and hs-CRP from before treatment and the second day after the treatment of PCI in 100 patients with ACS and compared with control. Results： The unstable angina pectoris （UAP） patient＇ blood levels of CD62p, GP Ⅱb/Ⅲa, FIB C and hs-CRP increased significantly compared with healthy control group （ all P〈0.01）and stable angina pectoris（SAP） （P〈0.05,P〈0.01 ,P〈0.05,P〈0.01,respectively）. The blood levels of CD62P,GP Ⅱb/Ⅲa, FIB- C and hs-CRP acute myocardial infarction（AMI） group increased significantly compared with UAP group （P〈 0. 05, P〈0.01 ,P〈0. 05, P〈0. 01, respectively）. There were different significantly of above factor levels with the severity of lesions,ie, acute blood vessel occlusion group much more than three lesion group（P〈0.05）, three lesion group more than two lesion group（P〈0.05）and two lesion group more than one lesion group（P〈0.05, P〈 0. 05,P〈0. 05, P〈0.01, respectively）. These factors increased significantly in post-PCI group compared with pre-PCI group （all P〈0.01）. Conelusions：Platelet activation and inflammation played an important role in the occurrence and development of ACS. The platelet and inflammation factors were obviously activated to some extent in patients with ACS after PCI.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2009年第7期488-491,共4页
Journal of Clinical Cardiology
