摘要
目的：比较静脉滴注（静滴）尼卡地平与酚妥拉明对老年高血压急症病人的降压疗效。方法：老年高血压急症病人６３例，分成２组，尼卡地平组３４例，用尼卡地平注射液２５ｍｇ加入５％葡萄糖注射液（ＧＳ）２５０ｍＬ中静滴。酚妥拉明组２９例，用酚妥拉明１０ｍｇ溶于５％ＧＳ２５０ｍＬ中静滴，均于２ｈ内滴完。结果：尼卡地平降压显效率及总有效率分别为７９％和９７％，酚妥拉明分别为７２％和９３％（Ｐ＞０．０５）。治疗２ｈ后比较，尼卡地平组收缩压及舒张压分别下降６．５±２．０ｋＰａ和４．８±１．８ｋＰａ，而酚妥拉明组分别下降５±３ｋＰａ（２组比较Ｐ＞０．０５）和３．３±１．４ｋＰａ（２组比较Ｐ＜０．０５）。尼卡地平组起效（５ｍｉｎ）快于酚妥拉明组（１５ｍｉｎ）（Ｐ＜０．０１）。
AIM: To compare the anti-hypertensive effects of nicardipine and phentolamine on hypertension emergency in aged. METHODS: Sixty_three old patients with hypertension emergency were divided into 2 groups. In nicardipine group 34 patients were treated with nicardipine 25 mg in 5% glucose 250 mL, iv, gtt; In phentolamine group 29 patients were infused with phentolamine 10 mg in similar protocol. RESULTS: Both groups showed reduction of blood pressure. The excellent and total effective rates were 79% and 97% respectively for nicardipine group, while 72% and 93% for phentolamine group (P>0.05). At 2 h after infusion, the reductions of systolic and diastolic blood pressures were 6.5±2.0 kPa and 4.8±1.8 kPa in nicardipine group, while 5±3 kPa (P>0.05) and 3.3±1.4 kPa(P<0.05) in phentolamine group, respectively. The anti_hypertensive effect of nicardipine occurred more rapidly (5min) than that of phentolamine (15 min) (P<0.01). CONCLUSION: Intravenous infusion of nicardipine is superior to phentolamine in the treatment of hypertension emergency in aged.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
1998年第4期206-208,共3页
Chinese Journal of New Drugs and Clinical Remedies
关键词
尼卡地平
酚妥拉明
高血压
老年人
nicardipine
phentolamine
hypertension
aged
intravenous infusions
