摘要
建立了TLC法分离碱性药物牛磺罗定及有关物质2-氨基乙磺酰氯、2-氨基乙磺酰叠氮和2-氨基乙磺酰胺。以0.5%[Bmim]BF4甲醇溶液处理过的硅胶G板为固定相,0.2%二乙胺的甲醇溶液为展开剂,4个化合物经薄层色谱展开后达到完全分离,斑点清晰、无拖尾现象。
A TLC method was established for the separation of taurolidine and related substances 2-aminoethyl sulfonyl chloride, 2-aminoethyl sulfonyl azide and 2-aminoethyl sulfonamide. The silica gel G plate saturated by 1-butyl- 3-methylimidazolium tetrafluoroborate ionic liquid was used as the stationary phase, and methanol containing 0.2% diethylamine was used as the developing agent.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2009年第7期526-528,共3页
Chinese Journal of Pharmaceuticals
