摘要
目的:研究水牛角不同相对分子质量酶解液的药理作用。方法:通过观察小鼠对戊巴比妥钠催眠作用的反应、对脂多糖引起死亡的抵抗及用药后小鼠凝血时间、自发活动和对抗感染的影响和作用,研究水牛角不同相对分子质量酶解液的药理作用。结果:与生理盐水(NS)对照组比较,相对分子质量<3kD和10～30kD的酶解液有明显的镇静作用(P<0.01);相对分子质量<3kD酶解液有显著的抵抗脂多糖引起的死亡作用(P<0.05);相对分子质量>30kD酶解液有明显的止血作用(P<0.01);相对分子质量>5但<10kD酶解液有明显的抑制自发活动作用(P<0.01);相对分子质量>5但<10kD组和10～30kD组有明显的提高抗细菌感染作用(P<0.01)。结论:水牛角不同相对分子质量酶解液,药理作用不同。
Objective： To study the pharmacological effects of different molecular weight enzymolysis liquid from cornu bubali. Methods： It was observed to research the pharmacological effects of different molecular weight enzymolysis liquid that the influence and action of mice to the pentobarbitol sodium hypnosis, LPS caused death, coagulation time, spontaneous activity, anti-infection and so on. Results： Compared with the NS control group, 〈3 kD and the 10-30 kD enzymolysis fluid had obvious sedative effect （P〈0.01）. The〈3 kD group had remarkable resistance to LPS caused death （P〈0.05）. The 〉30 kD group had obvious hemostatic function （P〈0.01）.The 5-10 kD group had obvious inhibition to the spontaneous activity （P〈0.01）.The 5-10 kD group and the 10-30 kD group had obvious enhancement to the anti-infection （P〈0.01）. Conclusion： The different molecular weight enzymolysis liquid from cornu bubali has different pharmacological effects.
出处
《中国当代医药》
2009年第13期16-17,共2页
China Modern Medicine
基金
济南市卫生局课题资助(项目编号:济卫科计2006-35)
关键词
水牛角
相对分子质量
酶解液
药理作用
Cornu bubali
Different molecular weight
Enzymolysis liquid
Pharmacological effects
