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肝癌患者肝组织中CD105的表达及临床意义 被引量：1

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摘要 目的:探讨肝癌患者肝组织中CD105的表达特征及其与预后和临床病理参数的关系。方法:选取原发性肝癌根治切除术的石蜡包埋标本100例,用CD105单克隆抗体进行免疫组化染色,进行CD105标记的微血管密度(MVD-CD105)定量计数,并与相应患者的临床病理学参数和无病生存期进行统计学分析。结果:肿瘤组织内CD105染色阳性率为100%(100/100);癌旁肝硬化组织内染色阳性率为40.6%(28/69);癌旁正常组织染色阳性率为4%(4/100);非肝癌患者正常肝组织无阳性染色。肿瘤内MVD-CD105数值与TNM分期、有无静脉侵犯呈正相关(P<0.05)。将肿瘤组织内MVD值的均数作为分界,高MVD-CD105组较低MVD-CD105组的无病生存期明显降低(P<0.01);癌旁肝硬化组织内CD105阳性组的无病生存期较阴性组明显缩短(P<0.05)。结论:在肝癌患者肝组织中CD105主要表达在肝癌组织及癌旁肝硬化组织中;肿瘤内MVD-CD105能准确地评价肿瘤新生血管,预测原发性肝癌根治术后的复发、转移;癌旁肝硬化组织中CD105的阳性表达可能与癌变相关,CD105可以作为原发性肝癌血管治疗的靶点。
作者 曹永新 彭玉龙 张健 郭琳琅
机构地区 广东省东莞市东华医院肿瘤内科 南方医科大学珠江医院肿瘤科
出处 《实用医学杂志》 CAS 北大核心 2009年第14期2212-2214,共3页 The Journal of Practical Medicine
基金 广东省科技计划项目(编号:2007B030703001)
关键词 癌 肝细胞 血管发生 CD105
分类号 R735.7 [医药卫生—肿瘤]
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参考文献12

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同被引文献21

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实用医学杂志
2009年 第14期

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