摘要
目的探讨急性百草枯（PQ）中毒患者QT离散度（QTd）与心肌酶学变化及其意义。方法选择36例急性百草枯中毒患者和40例健康体检者，分别测定QT离散度、心肌酶，并进行组间比较。结果2组间QTd有统计学意义（P〈0．01）。中毒组心肌酶明显高于对照组（P〈0．01），其中死亡组QTd与心肌酶亦显著高于存活组（P〈0．01）。结论心肌酶与QTd在百草枯中毒24h内均明显增高和延长的病人，病情重、病死率高、预后差。早期动态监测QTd和心肌酶能客观评估病情程度和预后。
Objective To investigate the changes of myocardial enzymes and QT dispersion （QTd） in patients with acute paraquat （PQ） poisoning. Methods Peripheral blood samples were collected from 36 patients with PD poisoning within 24 h of the onset and from 40 sex and age-matched healthy controls. Serum creatine kinase （CK） and creatine kinase-MB （CK-MB） were measured. Electrocardiography was conducted for 3 cardiac cycles for every lead and the QTd was calculated. Results The serum levels of CK and CK-MB of the PD group were （209.01±49.31） U/L and （25.78±9.32） U/L respectively, both significantly higher than those of the controls [（99.07± 31.68） U/L and （17.29± 6.97） U/L respectively, both P〈0.01）. The QTd of the PD poisoning patients was （44.80± 11.24） ms, significantly longer than that of the controls [（32.40± 10.90） ms, P=0.0000 ]. The serum levels of CK and CK-MB of the surviving PD poisoning patients were （181.06±4.08） U/L and CK-MB[（19.45±9.09 ） U/L respectively, both significantly lower than those of the patients who died later [（378.00± 10.20） U/L and （56.88± 19.42 ）U/L, both P=0.0000]. The QTd of the surviving PD poisoning patients was （35.80± 11.24） ms, significantly shorter than that of the of the patients who died later [（47.01 ± 12.01） ms, P〈0.05]. Conclusion Increased levels of myocardial enzymes and extended QTd within 24 h after the onset are factors of bad prognosis.
出处
《中国急救复苏与灾害医学杂志》
2009年第7期471-472,共2页
China Journal of Emergency Resuscitation and Disaster Medicine
关键词
除草剂
百草枯
诊断
心肌酶学
心电描记术
Herbicides
Paraquat （PQ）
Diagnosis
Myocardial enzymes
Electrocardiogram
