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翼状胬肉扩大切除联合自体角膜缘干细胞移植术的临床疗效观察 被引量:2

Clinical effect of enlarged excision of pterygium combined with autologous corneal limbal stem cell transplantation
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摘要 目的:探讨翼状胬肉扩大切除联合自体带结膜瓣的角膜缘干细胞移植术的手术方法及其临床疗效。方法:选择达到或超过瞳孔缘的35例36眼翼状胬肉患者,其中有4眼为复发性,其余均为原发性,于显微镜下做扩大的翼状胬肉切除,包括变性的球筋膜,联合自体带结膜瓣的角膜缘干细胞移植术,术后随访6~24.4mo,中位数为14.6mo,观察术眼手术前后视力变化及术后复发情况。结果:术前视力为指数/眼前~0.6,中位数为0.25,术后1mo视力为指数/眼前~1.2,中位数为0.7(秩和检验u=5.325,P<0.01)。无1例术后复发,复发率为0。结论:翼状胬肉扩大切除联合自体带结膜瓣的角膜缘干细胞移植术,术后复发率低,视力提高显著,是治疗翼状胬肉的有效方法,其术后的长期疗效仍需进一步观察。 AIM : To evaluate the methods and curative effect of the enlarged excision of pterygium combined with autologous corneal limbal stem cell transplantation with conjunctival flap. METHODS: Thirty-five patients (36 eyes) with pterygium reaching or surpassing the pupil margin were studied. 4 eyes were recurrent pterygium, the others were initial, and all the patients underwent the microsurgery of excision of pterygium including the degenerating bulbal foscia, combined with autologous corneal limbal stem cell transplantation with conjunctival flap. The post-operative follow up period was 6-24.4 months; the median was 14.6 months; and the change of visual acuity and the recurrence rate were observed after surgery. RESULTS: The post-operative visual acuity was counting finger to 1.2, the median was 0.7 (rank test, u= 5.325,P〈0.01). No eye recurred. CONCLUSION: The enlarged excision of pterygium combined with autologous corneal limbal stem cell transplantation seems to be an effective treatment for pterygium with low recurrence rate and better visual acuity, and further research is necessary to observe the long term effect after surgery.
作者 李昂 范忠义
出处 《国际眼科杂志》 CAS 2009年第7期1365-1366,共2页 International Eye Science
关键词 翼状胬肉 角膜缘干细胞 复发 pterygium corneal limbal stem cell recurrence
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  • 1肖琼,黄菊天,葛钧.新鲜羊膜移植治疗翼状胬肉的临床疗效[J].中国实用眼科杂志,2005,23(1):32-33. 被引量:45
  • 2吴晓红,王文奇,李赵霞,尹忠贵.自体角膜缘干细胞移植和自体游离球结膜移植治疗翼状胬肉的疗效观察[J].国际眼科杂志,2004,4(6):1147-1149. 被引量:31
  • 3郭青,周朝晖,皮裕琍,李晓艳.羊膜和角膜干细胞移植治疗眼表疾病临床观察[J].中国实用眼科杂志,2006,24(12):1247-1249. 被引量:15
  • 4王雨生.翼状胬肉的治疗及其并发症[J].国外医学:眼科学分册,1994,18(2):116-121.
  • 5Luanratanakorn P, Ratanapakorn T, Suwan-Apichon O, et al. Randomised controlled study of conjunctival versus amniotic membrane graft in ptergium excision. Br J Ophthalmol 2006;90(12):1476-1480
  • 6Kwok LS, Coroneo MT. A model for pterygium formation. Cornea 1994;13(2):219-224
  • 7Wiley L, Sundar RN, Sun TT, et al. Regional heterogeneity in human corneal and limbal epithelia:an immunohistochemical evaluation. Invest Ophthalmol Vis Sci 1991;32(3):594-602
  • 8Dua HS, Azuara-Blanco A. Autoglogous limbal transplantation in patients with unilateral corneal stem cell deficiency. Br J Ophthalmol 2000;84(3):273-278
  • 9Dua HS, Azuara-Blanco A. Limbal stem cells of the comeal epithelium. SurvOphthalmol 2000 44:415
  • 10Dua HS, Azuara-Blanco A. Autograft limbal transplantation in patients with unilateral corneal stem-cell deficiency. Br J Ophthalmol 2000 84:273

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