摘要
目的:评价联合检测孕妇孕中期(14～19+6周)血清标志物甲胎蛋白、β-绒毛膜促性腺激素、游离雌三醇在产前筛查先天出生缺陷中的应用价值。方法:应用化学发光免疫分析技术检测2 149例孕妇孕中期血清标志物,并结合孕妇年龄、孕周、体质量等因素,应用仪器配套的产前筛查风险分析软件计算唐氏综合征、18-三体综合征和开放性脊柱裂的风险率,对高风险孕妇采用B超和/或细胞染色体检查进行确认,根据随访及诊断结果进行评估。结果:2 149例孕妇筛查出出生缺陷高风险136例,筛查阳性率为6.33%,其中唐氏综合征、开放性脊柱裂和18-三体综合征的筛查阳性率分别为4.14%,1.77%,0.42%。唐氏综合征检出率为66.67%,筛查假阳性率为3.75%;开放性脊柱裂检出率为100%,筛查假阳性率为1.85%。结论:化学发光免疫分析技术联合检测孕中期血清甲胎蛋白、β-绒毛膜促性腺激素和游离雌三醇筛查出生缺陷是可靠和有效的,结合产前诊断可减少出生缺陷的发生。
Objective To evaluate the effect of the serum markers of AFP, β-HCG and HE3 on screening of congenital fetal abnormality in the pregnant women at second trimester. Methods The serum markers were measured in 2 149 pregnant women at second trimester of gestation with chemiluminescent immunoassay, and were combined with correlation factors such as the age, gestational weeks and the weight of pregnant women, to estimate the probability of fetus suffering from Down＇s syndrome, open spina bifida and Trisomy 18 syndrome. Cell chromosomes and ultrasonography were also done in high risk patients. Analysis was carried out based on the results of follow-up survey. Results One hundred and thirty six （6.33 %） cases wind high risk of birth deficiency were found in preliminary screening from 2 149 pregnant women, in which the positive rates of Down＇s syndrome, open spina bifida and Trisomy 18 syndrome were 4. 14%, 1. 77% and 0. 42%, respectively. The positive rates were 66.67% and 100% and the false positive rates were 3.75% and 1.85% in Down＇s syndrome and open spina bifida. Conclusion The combined screening of maternal serum markers of AFP, β-HCG and uE3 is reliable and effective, and is the important measure to reduce birth deficiencify combined with prenatal diagnosis.
出处
《中华实用诊断与治疗杂志》
2009年第7期640-642,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
广东省茂名市科技计划项目(2008098)
