摘要
目的制备斑蝥素β-环糊精包合物,以达到提高药物水溶性和减少黏膜刺激性的目的。方法采用饱和水溶液法制备包合物,采用显微镜、TLC和DSC对包合物进行验证。测定包合前后斑蝥素的水中溶解度。考察包合前后斑蝥素对大鼠胃黏膜的刺激性。结果制备了斑蝥素β-环糊精包合物。斑蝥素的溶解度较包合前提高了11.8倍。包合物未见黏膜刺激。结论斑蝥素制成包合物可以达到提高药物水溶性和减少药物黏膜刺激性的目的。
OBJECTIVE To prepare the inclusion complex of cantharidin-β-cyclodextrin in order to increase the solubility and reduce the mucosal stimulus. METHODS The inclusion complex were prepared by saturated solution method. Microscope, TLC and DSC were used to verify the complex. The solubility and mucosal stimulus of cantharidin before and after clathration were investigated, respectively. RESULTS The solubility of cantharidin was increased by 11.8 times after ctathration. The mucosal stimulus was not observed. CONCLUSION The cantharidin-β-cyclodextrin inclusion complex can increase the solublity and reduce the mucosal stimulus.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2009年第13期1002-1004,共3页
Chinese Pharmaceutical Journal
基金
中央级公益性科研院所基本科研业务专项基金(No.070503)
关键词
斑蝥素
伊环糊精
包合物
黏膜刺激
cantharidin
β-cyclodextrin
inclusion
mucosal stimulus
