摘要
为研究肝硬化患者血清肿瘤坏死因子(TNF-α)、白介素-8(IL-8)变化与肝功能Child-pugh分级的关系及临床意义,本文对46例肝硬化患者按Child-pugh肝功能分级标准分为A、B、C三组,并设正常对照组30名,采用放射免疫分析法(RIA)分别测定他们的血清TNF-α、IL-8值,同时测定血清总胆红素(TBiL)、谷丙转氨酶(ALT)、白蛋白(ALB)、透明质酸(HA)、层粘蛋白(LN)和III型前胶原(PCIII)。结果显示,肝硬化患者TNF-α、IL-8值较正常组明显升高(P<0.01),且A、B、C三组TNF-α、IL-8水平依次递增,各组间比较差异显著(P<0.01或P<0.05)。以上数据表明,肝硬化患者血清TNF-α及IL-8水平是反映肝功能损害程度及病情预测的重要指标。
To explore clinical significance of changes of serum tumor necrosis factor （TNF-α） and iterleukin-8 （IL-8） levels in patients with liver cirrhosis, forty-six patients with liver cirrhosis were classified into A, B and C group with Child-Pugh grades based on the liver dysfunction, and 30 normal people as control group. The serum TNF-α and IL-8 levels in each group were detected by RIA. The serum levels of TBiL, ALT, ALB, HA, LN and PCIII were also detected. The results showed that the serum TNF-α and IL-8 levels in patients with liver cirrhosis were significantly higher than that of control group（P 〈0.01 ）. The serum TNF-α and IL-8 levels in patients with liver cirrhosis were increased as the changes of Child Pugh Score with the sequence of C 〉 B 〉 A （P 〈0. 01 ）. The results indicate that the serum TNF-α and IL-8 levels in patients with liver cirrhosis might be regarded as an important index to reflect the degree of liver dysfunction.
出处
《标记免疫分析与临床》
CAS
2009年第3期129-131,共3页
Labeled Immunoassays and Clinical Medicine
关键词
肝硬化
TNF-Α
IL-8
Liver cirrhosis
Tumor necrosis factor - alpha
Iterleukin-8
