摘要
目的探讨妊娠期糖代谢异常与妊娠结局的关系。方法选取2008年1-6月在陕西省妇幼保健院进行产前检查的1636名孕妇，于24～28周进行50g葡萄糖筛查试验，异常者行75g糖耐量试验，按糖代谢异常情况分为妊娠期糖尿病组（69例）和妊娠期糖耐量受损组（124例）；选取糖代谢正常的孕妇300例为对照组，追踪至分娩，分析妊娠期糖代谢异常对妊娠结局的影响。结果妊娠期糖尿病发生率为4．21％，妊娠期糖耐量受损发生率为7．58％，妊娠期糖尿病组的妊娠期高血压疾病、羊水过多、胎膜早破、早产等发生率显著高于对照组（Χ^2分别为4．660、11．530、5．193、4．661，均P〈0．05）；妊娠期糖耐量受损但羊水过多，胎膜早破的的发生率明显高于对照组（Χ^2分别为12．450、6．325，均P〈0．05）；妊娠期糖尿病组和妊娠期糖耐量受损组的剖宫产率显著高于对照组（Χ^2分别为17．967、11．861，均P〈0．05）。结论妊娠期糖尿病组和妊娠期糖耐量受损组的产科并发症发生率显著增高，其剖宫产率亦明显增高。因此，应重视孕期糖尿病的筛查，做到早诊断、早治疗，加强孕期指导和监测，以降低母婴并发症的发生。
Objective To investigate relationship between abnormal gestational glucose metabolism and pregnancy outcome of the woman. Methods 1 636 pregnant women who received antenatal examination in Shannxi Provincial Maternal and Child Health Hospital in a period from January to June, 2008 were screened at their 24 - 28 weeks of gestation with 50g glucose challenge test （GCT）. Those pregnant women with abnormal GCT results further received oral 75g glucose tolerance test （OGTT）. According to OGTT results, the pregnant women were divided into 2 groups： GDM group （n = 69） and gestational impaired glucose tolerance group （GIGT group, n = 124）. 300 pregnant women with normal glucose metabolism were as controls. All of them were followed up untill delivery and the perinatal outcomes in the 3groups were compared. Results The incidence of GDM was 4.21% and that of GIGT was 7.58%. The incidences of hypertensive disorder complicating pregnancy, polyhydramnios, premature rupture of membrane and premature delivery in GDM group were higher than those in the control group （Χ^2 = 4. 660, 11. 530,5. 193,4. 661 respectively, all P 〈 0. 05）. In GIGT group , the incidences of polyhydramnios and premature rupture of membrane were significantly higher than those in the control group （Χ^2 = 12. 450,6. 325, respectively, both P 〈 0. 05 ）. Conclusion The pregnant women with GDM or GIGT have significantly high＇incidences of obstetric complications and rate of cesarean section. So, screening of GDM should be strengthened and early diagnosis, early treatment, gestational supervision and guidance should be carried out in order to reduce incidence rates of maternal and infantile complications.
出处
《中国妇幼健康研究》
2009年第4期420-422,共3页
Chinese Journal of Woman and Child Health Research
关键词
糖尿病
妊娠
妊娠结局
治疗
diabetes mellitus （ DM ）
pregnancy
pregnancy outcome
treatment
