摘要
目的:检测基质金属蛋白酶-9(MMP-9)与血管内皮生长因子(VEGF)在寻常型银屑病(PV)患者血清中的表达。方法:采用ELISA法检测42例PV血清中MMP-9和VEGF水平,以30名正常人做对照。结果:PV患者血清中MMP-9和VEGF的水平均显著高于对照组(P<0.01);进行期患者显著高于静止期患者(P<0.05);血清浓度变化与PV严重程度指数PASI呈正相关。结论:PV患者血清MMP-9和VEGF水平有助于对PV病情的判断。
Objective： To detect serum levels of MMP - 9 and vascular endothelial growth factor （VEGF） in patients with psoriasis vulgaris. Methods： Serum levels of MMP - 9 and VEGF in 42 patients with psoriasis vulgaris and 30 healthy controls were measured by sandwich - ELISA. Results： Serum levels of MMP - 9 and VEGF were significantly higher in the psoriasis vulgaris than in controls （ P 〈0.01 ）. The serum levels were positively correlated to the severity of the disease and PASI. Conclusion： The level of MMP- 9 and VEGF may serve as a marker of the severity of psoriasis vulgaris.
出处
《中国麻风皮肤病杂志》
2009年第7期506-507,共2页
China Journal of Leprosy and Skin Diseases
基金
广东省自然科学基金(07001961)
广州市医药卫生科研项目(2007-YB-140)
