期刊文献+

2型糖尿病肾病患者血清脂蛋白(a)水平的试验观察 被引量:2

下载PDF
导出
摘要 脂蛋白(a)[Lipoprotein(a)]是1963年由挪威遗传学家Berg在制备LDL抗体过程中首次发现并命名。由载脂蛋白A和载脂蛋白B100的LDL分子通过二硫键连接而成。近年来的研究证实,Lp(a)是动脉粥样硬化的独立危险因素,与心脑血管疾病、糖尿病、肾病综合征等多种疾病的发生有关。糖尿病(diabetes mellitus,DM)患者容易出现脂代谢异常,而脂代谢异常与糖尿病肾病(diabetic nephropathy,DN)的发生和发展密切相关。因此,本试验观察测定了158例2型糖尿病患者血清脂蛋白(a)及其他血脂指标的代谢情况,探讨其与肾功能损害之间的关系。
作者 王瑜 卢丹
出处 《国际检验医学杂志》 CAS 2009年第7期721-721,724,共2页 International Journal of Laboratory Medicine
  • 相关文献

参考文献2

二级参考文献16

  • 1Kalina A, Csaszar A, Fust G, et al. The association of serum lipoprotein(a) levels, apolipoprotein(a) size and (TTTTA)(n) polymorphism with coronary heart disease. Clin Chim Acta, 2001, 309(1): 45-51.
  • 2Gonbert S, Saint-Jore B, Giral P, et al. Molecular analysis of apo(a) fragmentation in polygenic hypercholesterolemia: characterization of a new plasma fragment pattern. Arterioscler Thromb Vasc Biol, 2001, 21(8): 1353-1358.
  • 3Yazici M, Demircan S, Durna K, et al. Lipoprotein(a) levels in patients with unstable angina and their relationship with atherothrombosis and myocardial damage. Int J Clin Pract, 2005, 59(2):150-155.
  • 4Schneider M, Witztum JL, Young SG, et al. High-level lipoprotein[a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins. J Lipid Res, 2005, 46(4):769-778.
  • 5Devlin CM, Lee SJ, Kuriakose G, et al, An apolipoprotein(a) peptide delays chylomicron remnant clearance and increases plasma remnant lipoproteins and atherosclerosis in vivo. Arterioscler Thromb Vasc Biol, 2005, 25(8):1704-1710.
  • 6Tsironis LD, Katsouras CS, Lourida ES, et al. Reduced PAF-acetylhydrolase activity associated with Lp(a) in patients with coronary artery disease. Atherosclerosis, 2004, 177(1): 193-201.
  • 7Buechler C, Ullrich H, Ritter M, et al. Lipoprotein (a) up-regulates the expression of the plasminogen activator inhibitor 2 in human blood monocytes. Blood, 2001, 97(4): 981-986.
  • 8Seed M, Ayres KL, Humphries SE, et al. Lipoprotein (a) as a predictor of myocardial infarction in middle-aged men. Am J Med,2001, 110(1): 22-27.
  • 9von-Eckardstein A, Schulte H, Cullen P, et al. Lipoprotein(a) further increases the risk of coronary events in men with high global cardiovascular risk. J Am Coll Cardiol, 2001, 37(2): 434-439.
  • 10Bilgen D, Sonmez H, Ekmekei H, et al. The relationship of TFPI,Lp(a), and oxidized LDL antibody levels in patients with coronary artery disease. Clin Biochem, 2005, 38(1): 92-96.

共引文献93

同被引文献15

引证文献2

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部