摘要
核糖体是细胞生长所需的蛋白质合成的动力工厂,每一个核糖体的大小为4兆而顿,有18S、5.8S、28S和5S四种RNA及80S等蛋白质组成,细胞中约有50%的RNA是核糖体RNA,这些RNA直接或间接地参与形成数百万的核糖体,因此,核糖体RNA基因的转录调控机制一直是细胞生长和细胞周期调控研究的热点,细胞通过进化已经形成一套完整的配合RNA聚合酶共同完成的核糖体RNA转录调控机制。本文从核糖体RNA基因结构出发,就染色质重塑、组蛋白乙酰化及细胞周期三个方面探讨核糖体RNA转录调控机制。
Ribosomes are the cellular factories responsible for protein synthesis in supporting cell growth. Each ribosome is some 4MDa in weight and consists of four RNAs, the 18S,5.8S, 28S and 5S rRNAs, and 80 or so proteins. A remarkable 50% of nascent RNA synthesis in a cell is accounted for by the transcription of ribosomal RNA （rRNA） genes, which direct and support the production of several millions of ribosomes. Although study on the regulation of ribosomal RNA genes is one of the intensively focused topics, it will not be possible to fully elucidate the mechanism if the investigation is out of the context of the expression and regulation of other ribosomal components and the control of cell growth. Eukaryotic cells have evolved a ribosomal DNA （rDNA） transcription machinery that incorporates RNA polymerases. Now we report it focus on chromatin remodeling, histone acetylation, and cell-cycle control.
出处
《廊坊师范学院学报（自然科学版）》
2009年第4期74-77,共4页
Journal of Langfang Normal University(Natural Science Edition)
关键词
核糖体RNA
转录
调控
ribosomal RNA
ranscription
regtdation
