摘要
目的探讨桑黄灵芝菌丝体胶囊作为保健食品的安全性。方法使用小鼠经口急性实验、遗传毒性实验和30 d喂养实验对桑黄灵芝菌丝体胶囊的安全性进行评价。结果桑黄灵芝菌丝体胶囊对小鼠经口急性毒性LD50大于10 g/kg bw,属实际无毒级物质。Am es试验、微核实验和精子畸形实验结果均为阴性。大鼠30 d喂养实验结果显示桑黄灵芝菌丝体胶囊对大鼠30 d喂养各项观察指标未见毒性作用。结论在本次实验条件下,桑黄灵芝菌丝体胶囊属于实际无毒物质,未显示有遗传毒性和亚急性毒性作用。
Objective To study the security of Phellinus igniarius and Glossy ganoderma Capsule. Methods Acute toxicity test, Ames test, micronucleus test of bone marrow PCE cell, sperm shape abnormality test and thirty - day feeding study were performed in mice. Results The Phellinuz igniarius and Glossy ganoderma Capsule belonged to actually non - toxicity. The results of genetic toxicity test including Ames test, micronucleus test and sperm shape abnormality test were all negative. The result of thirty - day feeding study was also negative. Conclusion The Phellinus igniarius and Glossy ganoderma Capsule is a substance with no toxicity and has not genetic toxicity and subacute toxicity.
出处
《中国预防医学杂志》
CAS
2009年第7期584-587,共4页
Chinese Preventive Medicine
关键词
桑黄菌
灵芝菌
急性毒性实验
遗传毒性实验
大鼠30d喂养实验
Phellinus igniarius
Glossy ganoderma
Acute toxicity test
Genetic toxicity
Thirty- day feeding study
