摘要
目的探讨碳酸锂联合喹硫平治疗急性躁狂发作的临床疗效和安全性。方法将90例急性躁狂发作患者随机分为两组各45例，两组均口服碳酸锂治疗，研究组在此基础上联合喹硫平治疗，观察8w。于治疗前及治疗第1w、2w、4w、6w、8w末采用Beck-Rafaelsen躁狂量表及副反应量表评定临床疗效及不良反应。结果治疗后研究组有效率显著高于对照组（P〈0．05）；治疗2w、4w、6w末Beck-Rafaelsen躁狂量表总分均较对照组下降显著（P〈0．05）。两组不良反应程度较轻微，发生率及副反应量表总分均无显著性差异（P〉0．05）；研究组合并应用氯硝西泮率显著低于对照组（P〈0．01）。结论碳酸锂联合喹硫平治疗躁狂发作较单用碳酸锂起效更快，疗效更显著，且不良反应发生率较低，程度较轻微，是临床治疗急性躁狂发作的有效措施之一。
Objeceive To explore the efficacy and safety of lithium carbonate plus quetiapine in the treatment of acute manic episode. Methods 90 patients with acute manic episode were randomly divided into two troups of 45 ones each, both groups took orally lithium carbonate,and research group was added quetiapine to for 8 weeks. Efficaeies were assessed with the Beeh Rafaelsen Mania Rating Scale （BRMS） and adverse reactions with the Treatment Emergent Symptom Scale （TESS） before treatment and at the end of the 1^st, 2^nd, 4^th, 6^th and 8^th week treatment. Results After treatment, effective rate was significantly higher in the research than in the control group（P〈0.05） ; total scores of the BRMS lowered more significantly in the research than in the control group at the end of the 2^nd ,4^th and 6^th week（P〈0.05）. Adverse reactions of both groups were mild and there were no significant differences in incidences of adverse reactions and total scores of the TESS（P〉0.05） ;The rate of combining clonazepam was significantly lower in the research than in the control group（P〈0.01）. Conclusion Lithium carbonaste combined with quetiapine has an advantage over single lithium carbonade,takes effect quicker, its efficacy is more significant,has lower and mild adverse reactions ans is one of effective methods treating acute manic episode.
出处
《临床心身疾病杂志》
CAS
2009年第4期328-329,共2页
Journal of Clinical Psychosomatic Diseases
