摘要
目的探讨巨噬细胞移动抑制因子（MIF）和细胞周期蛋白D1（cyclinD1）的表达及其与胰腺癌临床病理特征的关系及意义。方法免疫组化方法检测胰腺肿瘤和正常胰腺组织中MIF和CyclinD1的表达，分析其表达与胰腺肿瘤临床病理特征的关系。结果89例胰腺癌组织中MIF和CyclinD1阳性表达率分别为88．8％和50．6％。临床分期Ⅰ、Ⅱ、Ⅲ、Ⅳ期病例中MIF表达率分别为69．2％、94．7％、96．4％、100％，Ⅰ期与各期之间表达率的差异均有统计学意义（P〈0．05）；CyclinD1表达率分别为30．8％、47．4％、33．3％、68．8％。Ⅰ期表达率与Ⅲ、Ⅳ期之间的差异均有统计学意义（P〈0．05），与Ⅱ期之间差异无统计学意义。MIF表达与CyclinD1表达呈正相关（P〈0．05）。伴淋巴结转移病例中MIF和CyclinD1阳性表达率（97．5％和62．5％）均高于无淋巴结转移的胰腺肿瘤组织（81．6％和40．8％），差异均有统计学意义（P〈0．05）。发生肝转移的胰腺肿瘤组织中MIF表达率高于无肝转移组织（100％：85．9％，P〉0．05），CyclinD1表达率显著高于无肝转移组织（66．7％：46．5％，P〈0．05）。高、中、低分化组胰腺肿瘤组织中MIF和CyclinD1阳性表达率分别为61．9％、73．8％、96．2％和28．6％、45．2％、76．9％，3组之间差异均有统计学意义（P〈0．05）。结论MIF和CyclinD1过表达与胰腺肿瘤的临床分期、淋巴结和肝转移及组织分化密切相关。
Objective To evaluate the expression of macrophage migration inhibitor factor （MIF） and eyclinD1 in pancreatic carcinoma and their relationships with clinical pathology characteristics. Methods The expression of MIF and cyclinD1 in 89 carcinoma and 5 normal pancreatic tissues was detected with immunohistochemistry methods, and the relationships among MIF and cyclinD1 expression and elinicopathological factors were studied. Results The overexpression of MIF and cyclinD1 was found in 88. 8% , and 50. 6% of pancreatic carcinoma tissues respectively. The overexpression of MIF had a significant correlation with Ⅰ , Ⅱ, Ⅲ, Ⅳ tumor stage （69. 2%, 94. 7%, 96. 4%, 100%, P 〈0. 05） ,while the positive expression rate of cyclinD1 only had a significant correlation with tumor stages Ⅲ, Ⅳ（33.3%, 68. 8%, P 〈0. 05）. Both of the two proteins had a correlative tendency with pathological grade and lymph node metastasis. The different expression of MIF between pancreatic carcinoma with and without liver metastasis had no statistical significance, （ 100%, 85.9% , P 〉0. 05 ）while there was a statistically significant difference about cyclinD1 （66. 7% ,46. 5% ,P 〈 0. 05 ）. A significant positive correlation was also found between MIF and cyclinD1 （ P 〈 0. 05）. Conclusion The expression of MIF and CyclinD1 was higher in pancreatic cancer tissues than in normal tissue, and they may be associated with the malignant stage, tumor differentiation, local lymph node and liver metastasis of this tumor.
出处
《国际肿瘤学杂志》
CAS
2009年第7期550-553,共4页
Journal of International Oncology
基金
基金项目：广东省自然科学基金（5001776）
广州市科技计划项目（200523-E0381）
