摘要
目的探讨直立倾斜试验(HUTT)对儿童不明原因晕厥的诊断价值。方法晕厥组为2002年1月至2008年4月在北京、湖南、湖北、上海四地晕厥门诊就诊或住院的379例不明原因晕厥患儿,其中男171例,女208例;年龄3-18岁,平均(12±3)岁。所有患儿通过常规检查仍不能明确患儿晕厥的原因时,进行基础直立倾斜试验(BHUTT)或舌下含化硝酸甘油激发的倾斜试验(SNHUTT)检查。对照组为10名身体健康、无晕厥及晕厥先兆病史的正常儿童,其中男5名,女5名;年龄9-15岁,平均(11.4±2.1)岁,其心血管、神经系统、心电图、超声心动图及X线胸片检查均正常;所有正常儿童均进行BHUTr或SNHUTT。结果在379例患儿中,286例患儿为自主神经介导性晕厥(75.5%)。晕厥患儿中67例为体位性心动过速综合征(17.7%);157例为血管迷走性晕厥血管抑制型(41.4%);14例为血管迷走性晕厥心脏抑制型(3.7%);47例为血管迷走性晕厥混合型(12.4%);1例患儿为直立性低血压(0.3%);93例患儿仍为不明原因晕厥(24.5%)。在晕厥组和对照组中,BHUTT的诊断阳性率分别为55.9%和0,SNHUTT的诊断阳性率分别为75.5%和20.0%。BHUTF阳性患者在BHUTF过程中出现阳性反应的时间平均为(16±12)min,阳性反应出现时的体位均为倾斜60°体位;SNHUTF阳性患儿在SNHUqT过程中出现阳性反应的时间平均为(6±4)min,阳性反应出现时的体位均为倾斜60°体位并舌下含化硝酸甘油。结论应用HUTT可较好地、客观地对儿童自主神经介导性晕厥进行诊断,SNHUTT具有较高的诊断阳性率,明显提高了BHUTT的诊断阳性率,且阳性反应时间明显低于BHUTT。
Objective To examine the diagnostic value of head-up tilt test in children with unexplained syncope (UPS). Methods A total of 379 children (171 males, 208 females) aged 3 -18 years, mean age( 12 ± 3 ) years with unexplained syncope from Beijing, Hunan, Hubei and Shanghai and undergoing baseline head-up tilt tests (BHUTT) or head-up tilt tests potentiated with nitroglycerine (SNHUTT) under a quiet circumstance were selected as the syncope group. Ten healthy children (5 males, 5 females) aged 9- 15 years with a mean age of (11.4 ± 2. 1 ) years,were recruited as the control group. SPSS 10. 0 software was used for data analysis. Results In 379 children with unexplained syncope, 67 (17.7%) were of postural orthostatic tachycardia syndrome (POTS), 157 (41.4%) of vasovagal syncope vasoinhibitory pattern, 14 (3.7%) of vasovagal syncope cardioinhibitory pattern, 47 (12. 4% ) of vasovagal syncope mixed pattern, 1 (0. 3% ) of orthostatic hypotension (OH) and 93 children (24. 5% ) of UPS. In syncope group and control group, the positive rate of BHUTT was 55.9% and 0 respectively and it was 75.5% and 20.0% respectively for SNHUTT. During BHUTT, the mean time of positive response occurrence was (16 ± 12) minutes, and the posture when positive response appeared was at a tilt angle of 60 degrees. For SNHUTT, the mean time of positive response occurrence was (6 ± 4) minutes and the posture was at a tilt angle of 60 degrees when potentiated with nitroglycerine. Conclusion HUTF is an objective diagnostic tool of UPS. With a high diagnostic positive rate of BHUTT. Meanwhile the time of positive response BHUTT. rate, SNHUTr can improve the diagnostic positive occurrence during SNHUTT is markedly shorter than
出处
《中华医学杂志》
CAS
CSCD
北大核心
2009年第28期1947-1950,共4页
National Medical Journal of China
基金
长江学者奖励计划
首都医学发展基金(2007-2003)