摘要
目的探讨结缔组织生长因子与转化生长因子-β1在胃癌组织中的表达及其意义。方法利用免疫组织化学方法检测50例胃癌组织和正常组织中CTGF、TGF-β1的表达,并分析其与胃癌临床病理因素之间的关系和意义。结果胃癌组织中CTGF、TGF-β1的阳性表达率均明显高于正常组织(P<0.05);CTGF的高表达与胃癌的分化程度、淋巴结转移与否、临床分期均密切相关(P<0.05);TGF-β1的高表达与胃癌的分化程度和淋巴结转移密切相关(P<0.05);相关分析显示在胃癌组织中CTGF和TGF-β1的表达呈正相关关系(rs=0.355,P=0.012)。结论CTGF和TGF-β1在胃癌组织中均呈现高表达,并且与胃癌的分化程度、淋巴结转移与否有关,两者联合检测可以作为胃癌早期诊断和预后判断的指标。
Objective To investigate the expression and significance of Conective tissue growth factor （CTGF） and Tranforming grouth factor - β1 （ TGF - β1 ） in gastric carcinoma. Methods The expression of CTGF and TGF -β1 in 50 patients with gastric cancer was examined by immunohistochemistry. Results The expression of CT- GF and TGF - β1 was higher in GC group than that of in normal （ P 〈 0.05 ） ; Expression of CTGF were highly correlated with the carcinoma＇s degree of differentiation, lymph node metastasis and clinical stage （ P 〈 0.05 ） ; Expression of TGF - β1 were highly correlated with the carcinoma＇s degree of differentiation and lymph node metastasis （ P 〈 0.05 ） too ; And CTGF and TGF - β1 overexpression were positively correlated in gastric carcinoma （ rs = 0. 355 ,P =0. 012）. Conclusion All of CTGF and TGF- β1were overexpressed in gastric carcinoma, and correlated with the differentiation and tlymph node metastasis. It is considered that detection of CTGF and TGF - β1 may serve as fairly good index for early diagnosis and evaluating the prognosis of gastric carcinoma.
出处
《青海医学院学报》
CAS
2009年第2期99-103,共5页
Journal of Qinghai Medical College
基金
青海大学医学院中青年研究基金课题(2006-ky-004)
