摘要
目的研究饮水中不同氟碘浓度对儿童氟斑牙及甲状腺功能的影响。方法选择河南省开封、通许2个县的4个村庄分别为饮水高氟区、高氟高碘区、高碘区及对照区;以本地出生的8～12岁儿童为调查对象。检查各调查点儿童氟斑牙及甲状腺肿患病率,并采用放射免疫分析法测定血清中游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)和促甲状腺激素(TSH)。结果儿童甲状腺肿大率分别为:高氟碘组19.2%,高碘组19.4%、高氟组12.7%、对照组8.3%,差异无统计学意义(P>0.05);儿童氟斑牙患病率分别为:高氟高碘组49.3%、高氟组46.5%,明显高于高碘组和对照组(P<0.05);2个氟病区氟斑牙患病率差异无统计学意义(P>0.05);4个调查点血清中FT3水平比较差异无统计学意义(P>0.05);高氟高碘组儿童血清FT4水平高于其余3组,差异有统计学意义(P<0.05);高氟高碘及高碘组儿童血清TSH水平高于高氟组和对照组,差异有统计学意义(P<0.05)。结论高碘及高氟高碘均可加重甲状腺肿的发病率;氟、碘对FT3的分泌影响不大;高碘促进TSH的分泌;高碘条件下,氟可促进FT4分泌。
Objective To investigate the effect of different concentrations of fluoride and iodine in drinking water on children＇s dental fluorosis and thyroid function. Methods According to different concentration of fluoride and iodine in drinking water, four villages in two counties of Henan provine were classified as high fluoride and iodine ,high fluoride ,high iodine,and control area. Children who were born and grew in the four araeas were chosen for dental fluorosis examination with Dean＇s method. The prevalence rate of the goiter,and the concentrations of FT3 ,FT4 and TSH in serum were detected with radio-immunoassay method among the children. Results The prevalence of goiter in children from high fluoride and iodine,high fluoride,high iodine and control areas were 19. 2% ,12. 7% ,19. 4% ,and 8.3% ,respectively. There was no significant difference in goiter prevalence among the four groups （ P 〉 0.05 ）. The prevalences of dental fluorosis were 49. 4% and 46. 5% in the children lived in high fluoride and iodine area and high fluoride area,rsepectively. No dental fluorlsis case was found in high iodine and control area. There was no significant difference in the concentration of serum FT3 among the children from the four areas （ P 〈 0. 05）. The content ratios of serum FT4 and TSH in children from high fluoride and iodine area were higher than that of in the children from the other three areas （ P 〈 0. 05 ）. There were no significant diffeience in serum FT4 between the children from high fluoride area, high iodine area and control area （ P 〉 0. 05 ）. The concentration of serum TSH of children from high fluoride and iodine area and high iodine area was higher than that of children from high fluoride area and control area. Conclusion High fluoride and iodine increase the prevalence of goiter. High iodine increases thd concentration of FT4. Fluoride can increase the concentration of FT4 under high iodine condition.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2009年第8期942-943,共2页
Chinese Journal of Public Health
基金
河南省医学科技攻关项目(20060374)
关键词
氟
碘
氟斑牙
甲状腺
儿童
饮水
fluoride
iodine
fluorosis
thyroid
children
drinking water
