摘要
目的观察早期血浆置换(PP)联合甲基强的松龙(MP)冲击治疗过敏性紫癜肾炎(HSPN)的临床疗效。方法分析10例行早期PP联合MP冲击治疗的HSPN患者的临床资料,并与12例甲基强的松龙冲击治疗的HSPN患者、18例应用常规剂量肾上腺皮质激素治疗的HSPN患者作对比。结果经早期PP联合MP冲击治疗后,8例患者尿常规阴转或明显好转,总有效率达80%。在使尿微量蛋白减低方面,较单用MP冲击治疗患者、常规治疗患者均显示了明显的优越性(P<0.05或P<0.01)。在PP联合MP冲击治疗过程中,无严重并发症发生。结论早期血浆置换联合甲基强的松龙冲击治疗是治疗HSPN可取的有效的方法。
Objective To observe the curative effect of the combined use of plasmapheresis（PP） and methylprednisolone（MP） on Henoch- Schonlein purpura nephritis（HSPN）. Methods A retrospective research was performed to analyze the clinical effect on 10 adolescents with HSPN treated by PP and MP pulse therapy（the PP ＋ MID group）, 12 cases by MP pulse therapy（MP group）, 15 cases by common close of adrenocortical hprmones（the control group）. Urine routine factors and urine trace protein were analyzed before and after these therapies. Resuits In PP ＋ MP group, 8 patients showed recovery or obvious improvement in urine routine factors, and the total effective rate was 80 %, much higher than in other groups. The concentration of urine trace protein was obviously lower in PP ＋ MP group than in those in MP group and the control group after being treated（ PP〈 0.05）. No serious complications were found. Conclusion Early plasmapheresis and pulse therapy with methyl- prednisolone should be an effective therapy for Henoch- Schnlein purpura nephritis.
出处
《山东医学高等专科学校学报》
2009年第4期290-292,共3页
Journal of Shandong Medical College
关键词
甲泼尼龙
紫癜
过敏性
肾炎
血浆置换
Methylprednisolone
Purpura
Henoch-Schonlein
Nephritis
Plasmapheresis.
