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肝癌患者活体供肝移植后肿瘤复发的相关因素

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摘要 肝移植能够去除肝脏肿瘤，同时治愈肝硬化，具有传统的肿瘤切除术无法比拟的优势，所以肝移植被认为是肝癌合并肝硬化患者较理想的治疗方法。由于尸体供肝来源相对缺乏，现在，国际上各大肝移植中心已较多的选择活体供肝移植（LDLT）治疗肝癌。随着LDLT增多及术后随访时间的延长，肿瘤的复发和转移逐渐成为影响肝癌受者术后存活率的主要因素之一。肝癌的复发及转移是一个多步骤、多环节的过程，其分子机制涉及癌基因、抑癌基因、转移相关基因、生长因子及其受体、粘附分子、细胞外基质、肿瘤血管及机体免疫等多个环节。同样，活体移植肝的肝癌复发和转移也是一多环节、多阶段的过程，有其特殊的规律。
作者 李长贤 李相成
机构地区 南京医科大学第一附属医院肝脏移植中心
出处 《中华器官移植杂志》 CAS CSCD 北大核心 2009年第8期510-511,共2页 Chinese Journal of Organ Transplantation
关键词 活体供肝移植 肝癌患者 肿瘤复发 转移相关基因 移植后 肝硬化患者 治疗方法 抑癌基因
分类号 R686 [医药卫生—骨科学]
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参考文献21

  • 1Gondolesi GE,Roayaie S,Munoz L,et al.Adult living donor liver transplantation for patients with hepatocellular carcinoma:extending UNOS priority criteria.Ann Surg,2004,239(2):142-149.
  • 2Todo S,Furukawa H; Japanese Study Group on Organ Transplantation.Living donor liver transplantation for adult patients with hepatocellular carcinoma:experience in Japan.Ann Surg,2004,240(3):451-159.
  • 3Takada Y,Ueda M,Ito T,et al.Living donor liver transplantation as a second-line therapeutic strategy for patients with hepatocellular carcinoma.Liver Transpl,2006,12(6):912-919.
  • 4Fisher RA,Kulik LM,Freise CE,et al.Hepatocellular carcinoma recurrence and death following living and deceased donor liver transplantation.Am J Transplant,2007,(6):1601-1608.
  • 5Roayaie S,Frischer JS,Emre SH,et al.Long-term results with multimodal adjuvant therapy and liver transplantation for the treatment of hepatocellular carcinomas larger than 5 centimeters.Ann Surg,2002,235(4):533-539.
  • 6Lee KW,Park JW,Joh JW,et al.Can we expand the Milan criteria for hepatocellular carcinoma in living donor liver transplantation? Transplant Proc,2004,36(8):2289-2290.
  • 7Figueras J,Ibanez L,Ramos E,et al.Selection criteria for liver transplantation in early-stage hepatocellular carcinoma with cirrhosis:results of a multicenter study.Liver Transpl,2001,7(10):877-883.
  • 8Ho MC,Wu YM,Hu RH,et al.Liver transplantation for patients with hepatocellular carcinoma.Transplant Proc,2004,36(8):2291-2292.
  • 9Marubashi S,Dono K,Nagano H,et al.Detection of AFP mRNA-expressing cells in the peripheral blood for prediction of HCC recurrence after living donor liver transplantation.Transpl Int,2007,20(7):576-582.
  • 10Vivarelli M,Cucchetti A,Piscaglia F,et al.Analysis of risk factors for tumor recurrence after liver transplantation for hepatocellular carcinoma:key role of immunosuppression.Liver Transpl,2005,11(5):497-503.

二级参考文献12

  • 1Mazzaferro V,Rondinara GF,Rossi G,et al.Milan multicenter experience in liver transplantation for hepatocellular carcinomal.Transplant Proc,1994,26:3557-3560.
  • 2Yazawa H,Kato T,Nakada T,et al.Glucocorticoid hormone suppression of human neutrophil-mediated tumor cell cytostasis.Int J Cancer,1999,81:74-80.
  • 3Ho WL,Wu CC,Yeh DC,et al.Roles of the glucocorticoid in resectable hepatocellular carcinoma.Surgery,2002,13:19-25.
  • 4Punch JD,Shieck VL,Campbell DA,et al.Corticosteroid withdrawal after liver transplantation.Surgery,1995,118 :783-788.
  • 5Everson G,Trouillot T,Wachs M,et al.Early steroid withdrawal in liver transplantation is safe and beneficial.Liver Transplant Surg,1999,5 :48.
  • 6Pirenne J,Aerts R,Koshiba T,et al.Steroid-free immunosuppression during and after liver transplantation-a 3-yr followup report.Clin Transplant,2003,17 :177-182.
  • 7Innocenti F,Hepp J,Humeres R,et al.Rapid steroid taper and Neroal monotherapy in liver transplantation in Chile:a step in the right direction? Transplant Proc,2005,37:2179-2180.
  • 8Padbury R,Gunson B,Dousset B,et al.Steroid withdrawal from long term immunosuppression in liver allograft recipients.Transplantation,1993,55 :789.
  • 9Jain A,Kashyap R,Marsh W,et al.Reasons for long-term use of steroid in primary adult liver transplantation under tacrolimus.Transplantation,2001,71:1102-1106.
  • 10Stegall MD,Everson G,Schroter G,et al.Prednisone withdrawal late after adult liver transplantation reduces diabetes,hypertension and hypercholesterolemia without causing graft loss.Hepatology,1997,25:173.

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中华器官移植杂志
2009年 第8期

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