摘要
目的探讨广西地区汉族妊娠期糖尿病(GDM)与HIA-DQA1等位基因的相关性。方法采用聚合酶链反应-序列特异性引物法检测50例GDM孕妇和50例正常孕妇的HLA.DQAI基因型。结果GDM孕妇与正常孕妇相比较,HLA-DQA1*0501基因频率明显升高,差异有显著性(P=0.006)。HLA—DQA1*0101、0104、0201、0601等位基因频率在GDM孕妇中有增高趋势,但差异没有显著性(P均〉0.05)。GDM孕妇中HLA—DQA1*0102、0103、0301、0302和0401基因频率有降低趋势,差异亦无著性(P均〉0.05)。结论广西地区汉族GDM与HLA—DQA1基因相关,HLA—DQA1%0501基因可能为广西地区汉族GDM的易感基因,未发现与HIA—DQA1相关的GDM保护基因。
~ Objective To investigate the relationship between HLA-DQA1 gene polymorphism and gestational diabetes mellitus (GDM) in Guangxi Han nationality. Methods Fifty cases of GDM and fifty cases of normal pregnant women are detect HLA-DQA1 alleles by polymerase chain reaction-sequence specific primers (PCR-SSP). Results The gene frequency of HLA-DQA1 * 0501 increased in GDM group compared with control group (P = 0. 006). The gene frequencies of HLA-DQA1 * 0101,0lOd ,0201 and 0601 were increased in GDM group,but have no significant difference. The gene frequencies of HLA- DQA1 * 0102,0103,0301,0302 and 0401 were decreased in GDM group, but also have no significant difference. Conclusions HLA-DQA1 gene polymorphism is associated with GDM in Guangxi Han nationality. Alleles HLA-DQA1 * 0501 may be the susceptible gene of GDM in Guangxi Han nationality,but the protective gene of GDM is still not found.
出处
《临床内科杂志》
CAS
2009年第8期545-547,共3页
Journal of Clinical Internal Medicine
基金
广西教育厅基金(编号:桂教科研[2004]20号)