摘要
目的探讨血小板参数及纤溶酶原激活剂抑制物-1（PAI-1）、组织型纤溶酶原激活物（t—PA）在2型糖尿病患者中的变化。方法对50例2型糖尿病患者及2．50例健康体检者进行血小板（PLT）及其参数、PAl-1，t—PA的测定。结果与对照组相比，2型糖尿病患者中血小板（PLT）、平均血小板容积（MPV）、血小板体积分布宽度（PDW）及大血小板比率（P—LCR）均有显著性变化[MPV分别为12．11±1．21fl和11．07±0．96fl，PLT分别为（182±54）×10^9／L和（225±59）×10^9／L，P—LCR分别为41．25％土9．55％和32．14％±8．77％，PDW分别为17．06±4．26fl和14．85±3．12fl，P均〈0．01]，PAI-1含量显著高于对照组（109．1±19．8ng／ml和35.3±7．7ng／ml，P〈O．01），t-PA含量显著低于对照组（t0．3±4．7ng／ml和22．1±4．8ng／ml，P〈0．01）。结论血小板参数及PAI-1，t—PA在2型糖尿病患者中有显著性改变，提示糖尿病患者存在着血小板活化及纤溶活性减低的现象，凝血系统活性改变在糖尿病患者的病情发展及血栓性并发症的发生中起着-定的作用。
Objective To observe the variation of the platelet（PLT） and plasminogen activator inhibitor type l（PAI-1）,tis- sue-type plasiminogen activator（t-PA） in patients with type 2 diabetes mellitus. Methods 50 patients with type 2 diabetes mellitus were selected as test group and 50 healthy people were selected as control group. The blood of the patients and healthy control were measured with blood cell counter,PAI-1 and t-PA were measured with ELISA. Results In patients with type 2 diabetes mellitus,the platelets＇ parameters and PAT-I,t-PA changed significantly. The platelet was （182 ± 54） ）×10^9/L in patients with type 2 diabetes mellitus and （225±59）×10^9/L in controls;MPV were 12.11±1.21 fl vs 11. 07±0. 96 fl;P-LCR were 41.25%±9.55% vs 32. 14%±8. 77%;PDW were 17. 06±4. 26 fl vs 14.85±3.12 fl;PAI-1 were 109.1±19.8 ng/ml vs 35.3± 7.7 ng/ml;t-PA were 10.3±4.7 ng/ml vs 22.1±4.8 ng/ml,all the P〈0. 01. Conclu- sion The blood platelets＇ parameters and PAI-1 and t-PA in patients with type 2 diabetes mellitus changed significantly than healthy people. It means platelet activity could be enhanced and fibrinolytic system would he decreased in patients with type 2 diabetes mellitus.
出处
《现代检验医学杂志》
CAS
2009年第4期142-144,共3页
Journal of Modern Laboratory Medicine
关键词
血小板
平均血小板容积
纤溶酶原激活剂抑制物-1
组织型纤溶酶原激活物
2型糖尿病
platetet
mean platelet volume
plasminogen activator inhibitor type 1 （PAI-1）
tissue-type plasiminogen activator （t-PA）
type 2 diabetes mellitus
