摘要
目的:了解我院药品不良反应(ADR)发生的特点及一般规律。方法:对我院2003年1月1日～2008年12月31日各科室上报的1 832份ADR报告进行归类、分析。结果:我院ADR的发生率占同期住院患者总数的0.989%(1 832/185 207);ADR的男、女比例为1.186∶1,高发年龄段在41～80a之间(69.05%);发生率最高的给药途径是静脉给药(85.70%);引发ADR的药品种类中发生率居前5位的依次是抗微生物药(40.56%)、抗肿瘤药(11.35%)、营养类药(11.24%)、循环系统药(8.79%)和血液系统药(7.21%);主要临床表现为皮肤及其附件损害(31.13%)、中枢神经系统损害(22.30%)、消化系统损害(21.59%)等,所有症状在停药、改用其它药物和治疗后消失或缓解,无一例患者死亡。结论:加强ADR监测、报告、诊断和处理对确保安全用药至关重要。
OBJECTIVE： To probe into the characteristics and regularity of the adverse drug reaction （ADR） occurred in our hospital. METHODS： 1 832 ADR cases reported by clinical departments from Jan. 1,2003 to Dec. 31, 2008 were classified and analyzed. RESULTS： 0.989% （1 832/185 207） of the inpatients had ADR, with the ratio of male to female at 1 186 ： 1, and patients aged from 41 to 80 years accounted for 69.05% ; 85.70% of the ADR cases were induced intravenously. Topping the list in terms of the incidence of ADR in descending order were antibiosis （40.56%）, antineoplastic agents （11.35%）, nutriceutical agents （11.24%）, drugs for cardiovascular system （8.79%） and drugs for hematological system （7.21%）. The ADR manifested mainly as lesions of skin and its appendents （31.13%）, damage of nervous system （22.30%） and damage of digestive system （21.59%） etc. All symptoms disappeared or relieved after drug withdrawal or change to other drugs or treatment, and none died. CONCLUSION： Tightening the monitoring, reporting, diagnosis and treatment of ADR is of utmost importance for patients＇ medication safety.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第23期1814-1816,共3页
China Pharmacy
关键词
药品不良反应
报告
分析
Adverse drug reaction
Report
Analysis
