摘要
目的:研究妇宝胶囊的止血机制。方法:大鼠给药后测定组织纤溶酶原激活物(t-PA)和纤溶酶原激活物抑制物(PAI-1)的活性;家兔给药后测定其血小板聚集率和血小板α-颗粒膜蛋白-140(GMP-140)的含量。结果:给予大鼠妇宝胶囊内容物4.0、8.0g/(kg·d),家兔3.0、6.0g/(kg·d),共6d,后测定大鼠t-PA的活性降低(P<0.01)、PAI-1的活性提高(P<0.01),但家兔血小板聚集和血小板α-颗粒膜蛋白-140的含量未产生明显的影响(P>0.05)。结论:妇宝胶囊的止血机制之一是通过抑制纤维蛋白溶解系统达到目的。
Objective： To study the hemostatic mechanism of Fubao Capsule. Methods： The activities of the tissue plas minogen activator （t-PA） and the plasminogen activator inhibitor-1 in big mice were measured and the platelet aggregating function and the content of α-membranee-coating granules protein （GMP-140） were observed. Results： The activity of the tissue plasminogen activator （t-PA） was reduced and the plasminogen activator inhibitor-1 was increased after oral Fubao capsule 4.0,8.0 g/（kg-d） for six days in big mice （P〈0.01）.In the meantime,there were no any effect on the platelet aggregating function and the content of α-membranee-coating granules protein（GMP-140） after oral Fubao capsule 3.0,6.0 g/（kg·d） for six days in rabbits （P〉0.05）. Conclusion： One of the hemostatic mechanism of Fubao Capsule is inhibitive to the fibrinoly- sis system.
出处
《中国当代医药》
2009年第16期5-6,共2页
China Modern Medicine
关键词
妇宝胶囊
止血机制
纤溶酶原激活物
纤溶酶原激活物抑制物
血小板聚集
血小板
α-颗粒膜蛋白-140
Fubao capsules
Hemostatic mechanism
Tissue plasminogen activator
Plasminogen activator inhibitor-1
Platelet aggregation
Platelet α-membranee-coating granules protein
