摘要
目的:观察益气养阴法对中晚期恶性肿瘤患者化疗后生存质量的影响。方法:将63例临床分期为Ⅲ、Ⅳ的恶性肿瘤患者随机分为对照组27例和中药组36例,分别予一线化疗方案及常规对症支持治疗基础上,中药组予益气养阴法组方中药汤剂口服,日2次,共14d。3周期后比较两组卡式评分、临床症状及机体T细胞亚群变化。结果:中药组在改善患者KPS评分和临床症状积分方面明显优于对照组(P<0.05);化疗后,对照组T细胞亚群较治疗前下降(P<0.05),呈现抑制状态,而中药组CD3、CD4、CD4/CD8均较治疗前升高(P<0.05),与对照组比较呈显著性差异(P<0.01,P<0.05)。结论:运用益气养阴法配合中晚期恶性肿瘤化疗可改善患者不适症状,提高患者生存质量,并调节化疗后机体的免疫抑制状态;而其免疫调节作用可能是其改善中晚期肿瘤患者生存质量的重要机制之一。
Objective：To observe improving the living quality of medium or late tumor patients after chemotherapy by additional application of TCM replenishing Qi and Nourishing Yin. Method： 63 cases of medium or late tumor patients were randomly divided into the control group （ n = 27 ） and the treatment group （n = 36 ）： The two groups were treated with chemotherapeutics therapy, while the treatment group after chemotherapy were treated with additional application of replenishing Qi and Nourishing Yin. Result： Compared to the control group, better improving clinical symptoms and KPS score points effects were achieved in the treatment group （ P 〈 0.05 ）. After chemotherapy, T cell subsets in the control group were decreased （ P 〈 0.05 ）, while CD3, CD4 and CD4/CD8 in the treatment group were higher than those in the control group （ P 〈 0.01 or P 〈 0.05 ）. Conclusion： Better effects can be achieved on improving the living quality, symptoms and immunity of patients with tumors in TCM replenishing Qi and nourishing yin after chemotherapy.
出处
《河北医学》
CAS
2009年第10期1155-1158,共4页
Hebei Medicine
关键词
中晚期恶性肿瘤
益气养阴
化
疗
生活质量
Medium or late tumor
Replenishing qi and nourishing yin
Chemotherapy
Living quality
