紫杉醇在恶性黑素瘤中的应用
Application of paclitaxel in malignant melanoma
摘要
紫杉醇（paclitaxel）是从紫杉（红豆杉）的树皮中提取的一种化合物，是近年来研究开发出的一类化学结构新颖、作用机理独特的新型抗肿瘤药物。其分子式为C47H51014N，分子质量853．9，具有高度亲脂性，不溶于水，血浆蛋白结合率89％-98％，终末半衰期平均值为5．3～17．4h，主要经肝脏代谢，肾脏清除仅5％。紫杉醇具有高度的抗肿瘤活性，临床已广泛用于多种肿瘤的治疗。本文就其在恶性黑素瘤中的应用综述如下。
出处
《中国美容医学》
CAS
2009年第8期1194-1196,共3页
Chinese Journal of Aesthetic Medicine
基金
国家高技术研究发展计划(863计划)(2007AA021802)
山东省科技攻关计划(2007GG20002044)
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