摘要
目的探讨中药丹参对慢性肾功能不全肾脏纤维化的治疗作用。方法以大鼠5/6肾切除作为慢性肾功能不全动物模型,术后1周随机分为未治疗(A)组、丹参(B)组、苯那普利(C)组及假手术(D)组。于手术后第12周处死大鼠,留取血浆及肾组织。检测血肌酐(Scr)、尿肌酐(Ucr)及尿素氮(BUN)。用半定量法评价肾小球硬化指数及肾小管间质损害积分。结果与假手术组相比,手术三组在术后12周Scr及BUN均显著升高,Ccr均显著降低(P<0.01)。与未处理组相比,丹参组和苯那普利组肾功能改善,肾小球硬化及间质纤维化程度减轻。结论丹参可以改善慢性肾功能不全大鼠肾功能及减轻肾组织纤维化。
Objective To investigate the effect of Danshen on renal fibrosis in chronic renal insufficiency. Methods Male Sprague - Dawley rats were subjected to 5/6 nepbrectomy （5/6Nx） or to sham operation. One week after second operation, rats were divided randomly into group untreatment （A） , group Danshen （B） , Benazepril（C） and group D was sham -operated. Animals were sacrificed at twelves weeks after surgery. Arterial blood sample, 24 hour urine, remnant kidney, were collected and used for biochemical measurements and histopathologieal studies. Blood urea nitrogen （ BUN）, serum and urinary ereatinine （Ser, Ucr） were determined. Results Ser and BUN, Creatinine clearance was significantly reduced in 5/ 6Nx groups compared with sham - operated group. In group B and C compared to the group A, Ser and BUN was reduced, Ccr was increased significantly. The glomerulosclerosis index and tubulointersitial injury scores were substantially lower in group B and C compared with untreated rats. Conclusion Danshen alleviated renal function and renal fibrosis in the remnant kidney.
出处
《中国医学创新》
CAS
2009年第23期15-16,共2页
Medical Innovation of China
关键词
慢性肾功能不全
纤维化
丹参
Renal insufficiency
Chronie
Renal fibrosis
Danshen
