摘要
为评价Ⅰ、Ⅱ期非小细胞肺癌（NSCLC）中血管浸润（BVI）和淋巴管浸润（LVI）的预后意义，随访76例Ⅰ、Ⅱ期NSCLC病人，HE切片中组织学观察各例NSCLC中的BVI和LVI，Pearsonx2检验分析组间差异，Kaplan－Meier乘积限法和Cox比例风险模型用于生存分析。病人平均年龄56．0岁±8.2岁，中位随访时间为51个月，3年、5年总体生存率分别为68％和64％；BVI（＋）占28％，LVI（＋）占0．7％，BVI（＋）／或LVI（十）占34％；单变量生存分析显示：BVI而非LVI与生存差显著相关（x2=8．66，p=0．003）；Cox回归多变量分析显示：脉管浸润（p=0．003）和淋巴结状况（p=0．01）是影响总体生存的独立预后因素。本研究提示：脉管浸润是评价Ⅰ、Ⅱ期NSCLC病人预后重要的病理因素。
In order to assess the prognostic value of blood vessel and lymphatic vessel invasion(BVI and LVI) in stage Ⅰ、Ⅱ resected nonsmall cell lung cancer. 76 resected patientsfrom stage Ⅰ and Ⅱ NSCLC were followed. BVI and LVI were evaluated by light microscope in hematoxylin stain slides. Association among variables were tested by the Pearson chi-square test. Sue vival were analyzed by kaplan -Meier product-limit methodand the multivariable Cox model. The pattens' mean age was 56±8. 2 years. Medianfollow-up was 5l months. Overall 3-year survival was 68% and overall 5-year sruvivalwas 64%. BVlwas present in 28% of NSCLC cases and LVI in 0. 70%. BVI(＋)/or LVI(＋) was present in 34% of NSCLC. In univariate analysis, BVI ut not LVI was associated with poor survival (x2＝ 8. 66, P ＝ 0. 003 ). Cox regression multivariate analysisshowed vessel invasion(p= 0. 003) and lymph node status (P= 0. 01) were independentpredictors for poor overall survival. Our study suggested that vessel invasion was important pathological factor in evaluating prognosis of stage Ⅰand Ⅱ NSCLC.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1998年第4期267-269,共3页
Cancer Research on Prevention and Treatment
关键词
肺肿瘤
非小细胞肺癌
血管浸润
淋巴管浸润
预后
non-small cell lung cancer
blood vessel invasion
lymphatic vessel
prognosis
