摘要
目的:探讨冷冻治疗对宫颈上皮内瘤变(CIN)1～2及高危型人乳头瘤病毒(HPV)感染的疗效及安全性。方法:选取2007年11月～2008年3月在我院门诊检查并冷冻治疗的CIN2、高危型HPV(+)的CIN1或慢性宫颈炎、CIN1合并慢性宫颈炎患者共35例。术后3个月评价高危型HPV感染转阴率及CIN治愈率等。术中、术后观察不良反应。结果:冷冻治疗后高危型HPV DNA转阴率为55.9%,HPV DNA含量明显下降(P<0.05)。CIN患者有27例(90%)治愈。冷冻治疗宫颈柱状上皮异位(糜烂)、湿疣的有效率分别为100%、87.5%;治疗后白带多的症状明显改善(P<0.01)。术中无严重不良事件发生、术后主要反应为阴道排液。结论:冷冻治疗CIN1～2及高危型HPV感染是安全、有效的。
Objective：To observe the safety and efficacy of cryosurgery-therapy for cervical intraepithelial neoplasia（CIN）1-2 and high-risk human papillomavirus（HPV）infeetion.Methods：Thirty cases of CIN1-2 with positive high-risk HPV or chronic cervicits and 5 cases of simple chronic cervicits with positive high-risk HPV were enrolled.Thirty four cases of them complicated with positive high-risk HPV.Eight cases of them complicated with condyloma.All patients underwent cryosurgery and were followed up.Liquid-based cytologic test（ LCT）,high-risk HPV DNA test and colposcopic examination were taken after 3 months.Results：High-risk HPV DNA positive rate was 97.7%（29/30）in CIN.The elimination of cervical high-risk HPV infection was 55.9% at 3 months.The cure rate of CIN1-2 at 3 months after cryosurgery was 90%.The efficacy rates of the therapy for erosion and condyloma were 100% and 87.5%,respectively.Four cases with cervical cysts were all cured. The main side effects was vaginal diseharge.Conclusion：CIN1-2 and high-risk HPV infection can be treated with cryosurgery.
出处
《中日友好医院学报》
2009年第4期205-207,共3页
Journal of China-Japan Friendship Hospital
关键词
宫颈上皮内瘤变
人乳头瘤病毒
冷冻
cervical intraepithelial neoplasia
human papillomavirus
cryosurgery
