摘要
目的:分析我院2001-2007年抗假单胞菌药物用量与肠杆菌科细菌耐药性的相关性,为临床合理使用抗菌药提供参考。方法:回顾性调查我院2001-2007年肠杆菌科细菌耐药率和常用抗假单胞菌药物的用量,进行相关性分析。结果:大肠埃希菌是我院分离的最常见阴性菌,对头孢他啶和头孢吡肟的耐药率逐年显著增加,头孢吡肟、美罗培南和哌拉西林/他唑巴坦的用药量明显增加,头孢他啶、阿米卡星和奈替米星的用药量明显降低,头孢他啶耐药的大肠埃希菌与头孢吡肟用量呈显著正相关(r=0.773,P=0.042)。结论:我院大肠埃希菌耐药性呈不断加重趋势,严格控制抗假单胞菌药物使用有助于控制肠杆菌科细菌耐药。
Objective： To investigate the correlations between the consumption of antipseudomonal agents and resistance in enterobacteriaceae from 2001 to 2007, and to provide useful information for rational use of antimierobial agents. Methods ： The resistant rates of enterobacteriaceae from 2001 to 2007 and the consumption of antipseudomonal agents in Peking University Third Hospital from 2001 to 2007 were retrospectively analyzed. Results： Escherichia coli（E, coli） was the most common gram-negative bacteria. The resistant rate of E. coli to ceftazidime and cefepime increased significantly, the annual consumption of cefepime, meropenem and piperacillin-tazobactam also increased significantly, but the consumption of ceftazidime, amikacin and netilmicin decreased significantly. The resistant rate of E. coli to ceftazidime was positively correlated with the consumption of cefepime （ r = 0. 773, P = 0. 042）. Conclusion ： Increasing trends of resistant rates of enterobacteriaceae to most of the antimicrobial agents have been noted from 2001 to 2007 ; the strict use of antipseudomonal agents will be important to control the resistance in enterobacteriaceae.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2009年第15期1468-1472,共5页
Chinese Journal of New Drugs
关键词
肠杆菌科细菌
耐药性
抗菌药物
cnterobacteriaceae
drug resistance
antibacterial agent
