摘要
精神分裂症是一种复杂的精神疾病,全世界约有1%的人患有这种疾病。以往的研究发现精神分裂症患者的脑容量比正常人小,且一些精神分裂症易感的DNA序列多态性也同时与脑的结构异常有关,这与精神分裂症的神经发育假说是吻合的。最近研究发现人的GULP1基因的两个SNP(rs2004888和rs4522565)与精神分裂症显著相关。为了研究这两个精神分裂症易感的SNP是否也符合神经发育假说,我们检测了791个正常人的这两个SNP的基因型并测量它们的脑容量,相关性分析发现这两个SNP和脑容量无关,说明GULP1的精神分裂症易感性存在更加复杂的机制。
Schizophrenia is a complex mental disease which affects about 1% of the world population. Previous studies reported that the brain volumes of the schizophrenia patients were much smaller than normal people and many schizophrenia susceptible genetic variants were associated with structural brain abnormalities in patients, which is consistent with the neurodevelopmental hypothesis of the etiology of schizophrenia. Recently, two SNPs （rs2004888 and rs452256） of GULP1 were found to be significantly associated with schizophrenia. In this study, to test whether these two SNP of GULP 1 are also consistent with the neurodevelopmental hypothesis, we genotyped the two SNPs in 791 Chinese individuals and measured their brain volumes.We found that the two SNPs have no association with brain volume, suggesting that the etiology of schizophrenia is much more complicated.
基金
云南省科技计划项目(2006C0083M)
