摘要
目的探讨晚期肺癌化疗患者医院感染的特点与危险因素,为减少恶性肿瘤化疗患者医院感染提供有价值的信息。方法回顾调查2004年4月-2008年3月医院肿瘤科收治的628例晚期肺癌化疗患者的临床资料,对医院感染各项危险因素分别进行单因素分析和统计学处理。结果共有119例肺癌化疗患者发生医院感染(18.9%),常见感染部位依次是呼吸道、胃肠道、泌尿道等;共84例患者病原菌培养阳性,培养分离出的病原菌97株,以革兰阴性杆菌为主(49.5%),其中铜绿假单胞菌最为常见,其次是大肠埃希菌等;革兰阳性球菌占27.8%,以金黄色葡萄球菌为主;真菌占22.7%。结论在晚期肺癌化疗患者中,中央型肺癌、复治患者、低蛋白血症、CD4+/CD8+比值低,各种侵入性操作、长期使用广谱抗菌药物、住院时间长是医院感染的危险因素,>Ⅲ级中性粒细胞下降、陪护感染是医院感染的高度危险因素。
OBJECTIVE To investigate the clinical characteristics and risk factors of nosocomial infection in advanced lung cancer patients during and after chemotherapy. METHODS A retrospective analysis of 119 cases suffered from nosocomial infections from 628 cases with lung cancer was made. RESULTS The nosocomial infection rate was 18.9%. The most common infection site was respiratory tract, followed by gastrointestinal and urinary tracts. The ratio of G- bacilli to total bacteria examined was 49.5%, and the bacilli were mainly Pseudomonas aeruginosa, followed by Escherichia coll. The ratio of G＋ bacilli and fungi to total bacteria examined were 27.8% and 22.7%, respectively. CONCLUSIONS It is found that the risk factors of nosocomial infection in lung cancer patients are central type of lung cancer, retreated patients, hypoalbuminosis, lower CD4^＋/CD8^＋ ratio, invasive operation, time of using broad-spectrum antibiotics and longer hospital stay and the higher risk factors are grades 3-4 neutropenia and infections due to accompanying persons.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2009年第15期1959-1961,共3页
Chinese Journal of Nosocomiology
关键词
晚期肺癌
化疗
医院感染
危险因素
Advanced lung cancer
Chemotherapy
Nosocomial infection
Risk factors
