摘要
目的观察注射用头孢唑肟钠在复方氨基酸注射液(18AA)配伍后,混合液放置时间与药物稳定性的关系。方法采用高效液相色谱法测量室温下注射用头孢唑肟钠与复方氨基酸注射液配伍后,放置4 h内配伍液的性状、pH值、不溶性微粒及含量的变化。结果注射用头孢唑肟钠与复方氨基酸注射液配伍后,性状、pH值及含量无明显变化。不溶性微粒与放置时间有关。结论注射用头孢唑肟钠在复方氨基酸注射液配伍后,应在2 h内使用。
Objective To study the compatible stability of Ceftizoxime Sodium for Injection in Compound Amino Acid Injection. Methods The contents of the Ceftizoxime Sodium for Injection were determined by HPLC at different time within 4 h after mixing with Compound Amino Acid Injection. and the appearance and pH values of the mixed solutions were observed as well Results No marked changes were noted in the contents, appearance and pH assay of the Ceftizoxime Sodium for Injection mixed with Compound Amino Acid Injection. Conclusion Ceftizoxime Sodium for Injection can be used within 2 h after mixing with Compound Amino Acid Injection at room temperature.
出处
《现代医院》
2009年第9期60-61,共2页
Modern Hospitals
关键词
注射用头孢唑肟钠
复方氨基酸注射液
配伍稳定性
Ceftizoximc Sodium for Injection, Compound Amino Acid Injection, Compatible Stability
