摘要
目的研究晚期血吸虫病(晚血)合并HBV感染对肝纤维化的影响。方法对94例晚血患者的肝脏活检组织进行HBsAg免疫组化检测,根据HBsAg是否阳性对病例进行分组。采用Masson三色、苦味酸天狼猩红特殊染色法,对患者慢性肝炎炎症活动和肝纤维化程度进行分级和分期。结果94例晚血患者中,合并HBV感染者40例(42.55%),43例患者(45.74%)肝组织中查出血吸虫卵。患者合并HBV感染后,慢性肝炎炎症活动程度及肝纤维化程度均较单纯晚血患者严重(P均<0.01);肝组织虫卵阳性与阴性患者肝纤维化程度差异均无统计学意义(P均>0.05)。结论晚血合并HBV感染患者肝脏炎症活动程度和肝纤维化程度均明显加重。
Objective To explore the impact of advanced schistosomiasis combined with HBV infection on liver fibrosis. Methods Liver biopsies tissues of 94 advanced schistosomiasis cases were collected and studied. HBsAg was detected by the immune histochemistry SP method,and the patients were grouped according to whether HBsAg was positive. Masson trichrome coloration and picrosirius red staining were used to determine the grade of inflammatory activity in chronic hepatitis and stage of liver fibrosis,respectively. Results Among the 94 cases of advanced schistosomiasis,40 cases（42.55%） were combined with HBV infection,43 cases（45.74%） with schistosome eggs in the hepatic tissue were detected. The level of inflammatory activity of chronic hepatitis and liver fibrosis in cases of advanced schistosomiasis combined with HBV were more severe than that with advanced schistosomiasis only（P〈0.01）. There was no significant difference in levels of liver fibrosis between patients with or without schistosome eggs in the hepatic tissue （P〉0.05）. Conclusion Both the level of inflammatory activity of chronic hepatitis and liver fibrosis become more severe in cases of advanced schistosomiasis combined with HBV infection.
出处
《中国血吸虫病防治杂志》
CAS
CSCD
北大核心
2009年第4期290-292,F0002,共4页
Chinese Journal of Schistosomiasis Control
基金
世界卫生组织/热带病研究和培训特别规划署资助项目(WHO/TDR)(A50240)
