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脂蛋白脂酶基因多态性与代谢综合征的膳食易感性研究 被引量:4

THE ASSOCIATION OF LIPOPROTEIN LIPASE GENE POLYMORPHISM WITH METABOLIC SYNDROME AND DIETARY PREDISPOSITION
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摘要 目的探讨脂蛋白酯酶(lipoprotein lipase,LPL)基因Ser447Stop位点多态性在人群中的分布以及与代谢综合征(metabolic syndrome,MS)和膳食因素的关系。方法用聚合酶链反应和限制性片段长度多态性方法(PCR-RFLP)方法检测222名MS人群以及222名正常对照人群的LPL基因Ser447Stop位点多态性,同时对研究对象进行体格检查、生化指标测定和膳食调查。结果(1)SS、SX和XX三种基因型的频率分别为85.6%,13.3%和1.1%,符合Hardy-Weinberg定律。MS人群和对照人群的基因型SS、SX、XX及等位基因Ser447和Stop447构成比无差异,三种基因型及等位基因Ser447和Stop447在性别上无显著差异。(2)调整性别和年龄后,三种基因型的甘油三酯(TG)水平差异有显著性意义,SS型的TG最高,XX型的TG最低。(3)调整性别、年龄和体质指数后,三种基因型的蛋白质和碳水化合物摄入差异有显著性。(4)调整性别、年龄和体质指数后,不同基因型人群的蛋白质摄入与血清TG水平的负相关性有显著性意义。结论LPL基因Ser447Stop位点多态性与血清TG水平有关,与蛋白质摄入量有关联:该位点多态性可能会影响对于MS人群膳食干预的易感性。 Objective To explore the genotype distribution of lipoprotein lipase gene polymorphism at Ser447Stop locus and its possible association with metabolic syndrome and dietary intakes. Method Ser447Stop polymorphism was determined by PCR-PFLP method in 222 adults with MS and 222 normal adults as control. Their physical examination, dietary investigation and levels of biochemical profile, including BG TG, TC and HDL-C were analyzed. Results (1) The genotype frequencies of Ser447Stop SS, SX and XX were 85.6%, 13.3% and 1.1% respectively, which were in agreement with Hardy-Weinberg equilibrium. There was no significant difference in frequencies of genotypes or allele between MS and the control, and between male and female. (2) After adjusting age and gender, the levels of serum TG were significantly different among three genotype groups, the highest in SS genotype and the lowest in XX genotype. (3) After adjusting age, gender and body mass index, the intakes of protein and carbohydrate were significantly different among three genotype groups. (4) There was significantly different in negative correlation between the intakes of protein and serum TG levels after adjusting age, gender and body mass index. Conclusion Lipoprotein lipase gene polymorphism influenced serum TG levels, while associated with protein intakes. It might contribute to the predisposition in metabolic syndrome response to dietary intervention.
出处 《营养学报》 CAS CSCD 北大核心 2009年第4期325-329,共5页 Acta Nutrimenta Sinica
基金 达能营养中心膳食营养研究与宣教基金资助项目(No.2006006)
关键词 脂蛋白酯酶 基因多态性 代谢综合征 Ser447Stop lipoprotein lipase gene polymorphism metabolic syndrome Ser447stop
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  • 1中华医学会糖尿病学分会代谢综合征研究协作组.中华医学会糖尿病学分会关于代谢综合征的建议[J].中国糖尿病杂志,2004,12(3):156-161. 被引量:3060
  • 2青岛市糖尿病流行病学调查组.青岛地区20~74岁人群糖尿病患病率调查[J].中华糖尿病杂志(1006-6187),2004,12(5):344-347. 被引量:50
  • 3Ordovas JM. Gene-diet interaction and plasma lipid response to dietary intervention. Curr Atheroscler Rep, 2001,3(3):200-208
  • 4Wallace AJ, Mann JI, Sutherland WHF, et al. Variants in the cholesterol estertransfer protein and lipoprotein lipase genes are predictors of plasma cholesterol response to dietary change. Atherosclerosis, 2000,152:327-336
  • 5Earl SF,Wayne HG,William HD,et al.Prevalence of the metabolic syndrome among US adults.JAMA,2002,287:356-359.
  • 6Henderson H,Kastelein J.Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipid and lipoproteins[J].J Lipid Res,1999,40:735-738.
  • 7Peacock E,Hansten A,Peter N E,et al.Associations between LPL gene polymorphism and plasma correlations of lipids,lipoproteins and lipase activities in young myocardial infarction survivors and age-matched healthy individuals from Sweden[J].Atherosclerosis,1992,97:171-185.
  • 8Nicklas BJ,Errell RE.Lipoprotein lipase gene variation is associated with adipose tissue lipoprotein lipase activity,and lipoprotein lipid and glucose concentrations in overweight postmenopausal women[J].Hum Genet,2000,106:420-424.
  • 9Jemaa R,Tuzet S,Portos C,et al.Lipoprotein lipase gene polymorphisms:associations with hypertriglyceridemia and body mass index in obese people[J].Int J Obes Relat Metab Disord,1995,19:270-274.
  • 10Ahn YI,Kamboh MI,Hamman RF,et al.Two DNA polymorphisms in the LPL gene and their associations with factors related to cardiovascular disease[J].J Lipid Res,1993,4:421-428.

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