摘要
为探讨突发性感音神经性聋（突聋）发病与血清细胞因子的关系，采用夹心法ELISA检测了32例突聋病人、15例慢性进行性感音神经性聋（进行性聋）病人和20例健康对照者血清肿瘤坏死因子（TNFα）和白细胞介素6（IL－6）水平。结果发现：突聋病人血清TNFα和IL－6水平分别为34．19±15．27和70.33±32．05（pg／ml），明显高于进行性聋病人和健康对照者（P＜0.05）；突聋重度聋组与中度聋组间，两种细胞因子含量比较，差异无显著性（P＞0．05）；突聋显效组、有效组和无效组间比较，差异无显著性（P＞0．05）。提示：血清TNFα和IL－6水平增高在突聋发病机理中可能起着重要作用，血清TNFα和IL－6含量改变与突聋病情严重程度及预后无关。
Serum level of tumor necrosis factor(TNFα) and interleukin 6(IL-6) were determined in 32 patients with sudden sensorineural hearing loss (SSHL), 15 patients with progressive sensorineural hearing loss(PSHL) and 20 normal controls by using enzyme-linked immunosorbent assay. The results showed that plasma TNFα and IL-6 levels in patients with SSHL were higher than those in PSHL group and in normal control group (P <0. 05). The study suggested that the TNFα and IL-6 played an important role in the pathogenesis of SSHL.
出处
《临床耳鼻咽喉科杂志》
CSCD
1998年第7期311-313,共3页
Journal of Clinical Otorhinolaryngology
