摘要
内皮祖细胞（endothelial progenitor cell，EPC）是起源于骨髓的一种干细胞，具有分化为成熟内皮细胞的能力，参与血管内皮修复和促进缺血组织的新生血管形成。EPC水平与缺血性脑血管病的发生和预后密切相关。EPC移植可改善缺血部位的血液供应、加速血脑屏障修复、促进神经功能恢复，因此在缺血性脑血管病领域可能有着广泛的应用前景。
Endothelial progenitor cell （EPC） is derived from a stern cell of bone marrow, it has the capacity of differentiating into mature endothelial cells. EPC involves in vascular endothelial repair and promotes neovascularization of the ischemic brain tissue. The EPC levels were closely correlated with the occurrence of ischemic cerebrovascular disease and the prognosis. EPC transplantation may improve the blood supply to an ischemic site, accelerate blood-brain barrier repair, and promote neurological functional recovery. Therefore, EPC may have broad application prospects in the field of ischemic cerebrovascular disease.
出处
《国际脑血管病杂志》
北大核心
2009年第7期545-548,共4页
International Journal of Cerebrovascular Diseases
关键词
内皮细胞
干细胞
脑缺血
卒中
动脉粥样硬化
endothelial cells
stem cells
cerebral ischemia
stroke
atherosclerosis
