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加巴喷丁在腹腔镜胆囊切除术麻醉期的效应及对术后疼痛的影响 被引量:8

Effect of gabapentin on postoperative pain during anaesthetic period of laparoscopic cholecystectomy
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摘要 目的:评价加巴喷丁在全麻前和全麻中的效应及对患者术后疼痛的影响。方法:40例ASAⅠ~Ⅱ级行择期腹腔镜胆囊切除术患者随机分为实验组和对照组,每组20例。实验组在术前2h口服加巴喷丁300mg,对照组口服安慰剂。进入手术室后评价患者的焦虑程度并记录。记录全麻诱导后及气管插管后即刻,1、2、5min的血压和心率。术后使用视觉模拟量表(VAS)在术后2、6、12、18及24h时间点评价患者静息状态下的疼痛程度并记录。采用Ramsay镇静评分评价患者的镇静情况。记录术后恶心呕吐、眩晕、呼吸抑制等不良反应的发生情况。结果:与对照组比较,实验组患者在术前的焦虑度评分更低,气管插管后的血压、心率变化更小,术后疼痛VAS评分明显降低,术后恶心呕吐的发生率更低;眩晕、呼吸抑制的发生率和术后镇静评分在2组相似。结论:在腹腔镜胆囊切除术前口服300mg加巴喷丁,可缓解患者的术前焦虑,降低喉镜操作和气管插管的反应,缓解术后疼痛和降低术后恶心呕吐的发生率,而且不会产生明显的不良反应。
作者 程远 熊源长
出处 《第二军医大学学报》 CAS CSCD 北大核心 2009年第8期972-974,共3页 Academic Journal of Second Military Medical University
基金 上海市科委基金(064119513)~~
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参考文献15

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